Enhancers are distal genomic elements critical for gene regulation and cell identify control
during development and diseases. Many human cancers were found to associate with …

The imbalanced regulation of metabolic homeostasis and energy production is highly
associated with inflammation, tumor growth, metastasis and cancer progression. Both …

The mechanistic understanding of nascent RNAs in transcriptional control remains limited.
Here, by a high sensitivity method methylation-inscribed nascent transcripts sequencing …

Mounting evidence supports the idea that transcriptional patterns serve as more specific
identifiers of active enhancers than histone marks; however, the optimal strategy to identify …

Most cells of the body contain molecular clocks, but the requirement of peripheral clocks for
rhythmicity and their effects on physiology are not well understood. We show that deletion of …

Despite extensive progress in developing anticancer therapies, therapy resistance remains
a major challenge that promotes disease relapse. The changes that lead to therapy …

Enhancers are important cis‐acting elements that can regulate gene transcription and cell
fate alongside promoters. In fact, many human cancers and diseases are associated with the …

Autophagy is a major contributor to anti-cancer therapy resistance. Many efforts have been
made to understand and overcome autophagy-mediated therapy resistance, but these …

Enzalutamide (Enz) is a next-generation androgen receptor (AR) antagonist used to treat
castration-resistant prostate cancer (CRPC). Unfortunately, the relapsing nature of CRPC …

Cancer is driven by both germline and somatic genetic changes. Efforts have been devoted
to characterizing essential genetic variations in cancer initiation and development. Most …