Obesity I: Overview and molecular and biochemical mechanisms

RH Lustig, D Collier, C Kassotis, TA Roepke… - Biochemical …, 2022 - Elsevier
Obesity is a chronic, relapsing condition characterized by excess body fat. Its prevalence
has increased globally since the 1970s, and the number of obese and overweight people is …

Obesity II: establishing causal links between chemical exposures and obesity

JJ Heindel, S Howard, K Agay-Shay, JP Arrebola… - Biochemical …, 2022 - Elsevier
Obesity is a multifactorial disease with both genetic and environmental components. The
prevailing view is that obesity results from an imbalance between energy intake and …

Dietary carbohydrates: role of quality and quantity in chronic disease

DS Ludwig, FB Hu, L Tappy, J Brand-Miller - Bmj, 2018 - bmj.com
Dietary carbohydrates: role of quality and quantity in chronic disease Page 1 the bmj | BMJ
2018;361:k2340 | doi: 10.1136/bmj.k2340 1 Science and PoliticS of nutrition Dietary …

Effects of sucrose and high fructose corn syrup consumption on spatial memory function and hippocampal neuroinflammation in adolescent rats

TM Hsu, VR Konanur, L Taing, R Usui… - …, 2015 - Wiley Online Library
Excessive consumption of added sugars negatively impacts metabolic systems; however,
effects on cognitive function are poorly understood. Also unknown is whether negative …

Obesogens: an emerging threat to public health

AS Janesick, B Blumberg - American journal of obstetrics and gynecology, 2016 - Elsevier
Endocrine disrupting chemicals (EDCs) are defined as exogenous chemicals, or mixtures of
chemicals, that can interfere with any aspect of hormone action. The field of endocrine …

[HTML][HTML] Mannose alters gut microbiome, prevents diet-induced obesity, and improves host metabolism

V Sharma, J Smolin, J Nayak, JE Ayala, DA Scott… - Cell reports, 2018 - cell.com
Mannose is an important monosaccharide for protein glycosylation in mammals but is an
inefficient cellular energy source. Using a C57BL6/J mouse model of diet-induced obesity …

Fructose, but not glucose, impairs insulin signaling in the three major insulin-sensitive tissues

M Baena, G Sangüesa, A Dávalos, MJ Latasa… - Scientific reports, 2016 - nature.com
Human studies support the relationship between high intake of fructose-sweetened
beverages and type 2 diabetes, but there is a debate on whether this effect is fructose …

Gestational diabetes and offspring birth size at elevated environmental pollutant exposures

D Valvi, Y Oulhote, P Weihe, C Dalgård… - Environment …, 2017 - Elsevier
Background Gestational diabetes mellitus (GDM) is associated with increased availability of
glucose and macronutrients in fetal circulation and macrosomia. Therefore, the role of GDM …

High-fructose diet in pregnancy leads to fetal programming of hypertension, insulin resistance, and obesity in adult offspring

AF Saad, J Dickerson, TB Kechichian, H Yin… - American Journal of …, 2016 - Elsevier
Background Consumption of fructose-rich diets in the United States is on the rise and
thought to be associated with obesity and cardiometabolic diseases. Objective We sought to …

Pediatric non-alcoholic fatty liver disease: nutritional origins and potential molecular mechanisms

A Mandala, RC Janssen, S Palle, KR Short… - Nutrients, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the number one chronic liver disease worldwide
and is estimated to affect nearly 40% of obese youth and up to 10% of the general pediatric …