With advances in tumour biology and immunology that continue to refine our understanding
of cancer, therapies are now being developed to treat cancers on the basis of specific …

Multiplicity Considerations in Clinical Trials | New England Journal of Medicine Skip to main
content The New England Journal of Medicine homepage Advanced Search SEARCH …

Background Dravet syndrome is a rare, treatment-resistant developmental epileptic
encephalopathy characterised by multiple types of frequent, disabling seizures …

Background Voriconazole has been recommended as primary treatment for patients with
invasive aspergillosis. Intravenous and tablet formulations of posaconazole that have …

PURPOSE Sunitinib, a multitargeted tyrosine kinase inhibitor (TKI), is approved for
advanced gastrointestinal stromal tumor (GIST) after imatinib failure. Ripretinib is a switch …

Background Multiple primary outcomes may be specified in randomised controlled trials
(RCTs). When analysing multiple outcomes it's important to control the family wise error rate …

Objective: Effective Skills to Empower Effective Men (ESTEEM) represents the first
intervention to address the psychological pathways through which minority stress …

Adopting a unifying theme based on maximum statistics, Multiple Comparisons Using R
describes the common underlying theory of multiple comparison procedures through …

Importance The optimal approach to the use of venoarterial extracorporeal membrane
oxygenation (ECMO) during cardiogenic shock is uncertain. Objective To determine whether …

Background Neurodegeneration is the pathological substrate that causes major disability in
secondary progressive multiple sclerosis. A synthesis of preclinical and clinical research …