Epstein Barr virus: development of vaccines and immune cell therapy for EBV-associated diseases

X Cui, CM Snapper - Frontiers in Immunology, 2021 - frontiersin.org
Epstein-Barr virus (EBV) is the first human tumor virus discovered and is strongly implicated
in the etiology of multiple lymphoid and epithelial cancers. Each year EBV associated …

Epstein–Barr virus: more than 50 years old and still providing surprises

LS Young, LF Yap, PG Murray - Nature reviews cancer, 2016 - nature.com
It is more than 50 years since the Epstein–Barr virus (EBV), the first human tumour virus, was
discovered. EBV has subsequently been found to be associated with a diverse range of …

Epstein–Barr virus-associated lymphomas

C Shannon-Lowe, AB Rickinson… - … Transactions of the …, 2017 - royalsocietypublishing.org
Epstein–Barr virus (EBV), originally discovered through its association with Burkitt
lymphoma, is now aetiologically linked to a remarkably wide range of lymphoproliferative …

The biology of Hodgkin's lymphoma

R Küppers - Nature Reviews Cancer, 2009 - nature.com
Hodgkin's lymphoma was first described in 1832. The aetiology of this lymphoma, however,
remained enigmatic for a long time. Only within the past 10 years has the B-cell nature of the …

The Epstein–Barr virus and the pathogenesis of lymphoma

M Vockerodt, LF Yap, C Shannon‐Lowe… - The Journal of …, 2015 - Wiley Online Library
Since the discovery in 1964 of the Epstein–Barr virus (EBV) in African Burkitt lymphoma, this
virus has been associated with a remarkably diverse range of cancer types. Because EBV …

The classical Hodgkin's lymphoma microenvironment and its role in promoting tumour growth and immune escape

D Aldinucci, A Gloghini, A Pinto… - The Journal of …, 2010 - Wiley Online Library
It has become clear that cancer is not merely a growth of autonomously proliferating cells,
but that other non‐malignant cell types are a functional part of the disease. Immune cells …

An etiological role for the Epstein-Barr virus in the pathogenesis of classical Hodgkin lymphoma

PG Murray, LS Young - Blood, The Journal of the American …, 2019 - ashpublications.org
Although a pathogenic role for the Epstein-Barr virus (EBV) is largely undisputed for tumors
that are consistently EBV genome positive (eg, nasopharyngeal carcinoma, endemic Burkitt …

Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survival

C Mancao, W Hammerschmidt - Blood, The Journal of the …, 2007 - ashpublications.org
Many cells latently infected with Epstein-Barr virus (EBV), including certain virus-associated
tumors, express latent membrane protein 2A (LMP2A), suggesting an important role for this …

Molecular biology of Hodgkin's and Reed/Sternberg cells in Hodgkin's lymphoma

A Bräuninger, R Schmitz, D Bechtel… - … journal of cancer, 2006 - Wiley Online Library
Abstract Hodgkin's and Reed/Sternberg (HRS) cells, the tumour cells in classical Hodgkin's
lymphoma (HL), represent transformed B cells in nearly all cases. The detection of …

Rescue of “crippled” germinal center B cells from apoptosis by Epstein-Barr virus

C Mancao, M Altmann, B Jungnickel… - Blood, 2005 - ashpublications.org
Epstein-Barr virus (EBV) is associated with B-cell lymphomas such as Hodgkin lymphoma,
Burkitt lymphoma, and post-transplantation lymphoma, which originate from clonal germinal …