Abstract Transposase-Accessible Chromatin followed by sequencing (ATAC-seq) is a simple protocol for detection of open chromatin. Computational footprinting, the search for …
T Shashikant, CA Ettensohn - Methods in cell biology, 2019 - Elsevier
Programs of gene transcription are controlled by cis-acting DNA elements, including enhancers, silencers, and promoters. Local accessibility of chromatin has proven to be a …
Background Chromatin dysregulation is associated with developmental disorders and cancer. Numerous methods for measuring genome-wide chromatin accessibility have been …
ED Tarbell, T Liu - Nucleic acids research, 2019 - academic.oup.com
ATAC-seq has been widely adopted to identify accessible chromatin regions across the genome. However, current data analysis still utilizes approaches initially designed for ChIP …
Diverse RNA 5′ ends are generated through both transcriptional and post-transcriptional processes. These important modes of gene regulation often vary across cell types and can …
H Asma, E Tieke, KD Deem, J Rahmat, T Dong… - Elife, 2024 - elifesciences.org
Annotation of newly sequenced genomes frequently includes genes, but rarely covers important non-coding genomic features such as the cis-regulatory modules—eg, enhancers …
JB Wolpe, AL Martins, MJ Guertin - NAR Genomics and …, 2023 - academic.oup.com
Chromatin accessibility assays have revolutionized the field of transcription regulation by providing single-nucleotide resolution measurements of regulatory features such as …
ZS Bohannan, A Mitrofanova - Computational and structural biotechnology …, 2019 - Elsevier
Deep sequencing genomic analysis is becoming increasingly common in clinical research and practice, enabling accurate identification of diagnostic, prognostic, and predictive …
Y Watanabe, Y Arai, N Kawashita, MS Ibrahim… - Journal of …, 2018 - Am Soc Microbiol
Transmission of avian influenza (AI) viruses to mammals involves phylogenetic bottlenecks that select small numbers of variants for transmission to new host species. However, little is …