Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis
In this review we propose that there are sex differences in how men and women enter onto
the path that can lead to addiction. Males are more likely than females to engage in risky …
the path that can lead to addiction. Males are more likely than females to engage in risky …
Sex differences in addictive disorders
Gender-dependent differences in the rate of initiation and frequency of misuse of addicting
drugs have been widely described. Yet, men and women also differ in their propensity to …
drugs have been widely described. Yet, men and women also differ in their propensity to …
Behavioral sex differences in cocaine and opioid use disorders: The role of gonadal hormones
Females are more vulnerable than males to many aspects of cocaine use disorder. This
vulnerability also translates to opioid use disorder, with females exhibiting stronger …
vulnerability also translates to opioid use disorder, with females exhibiting stronger …
Estradiol increases the sensitivity of ventral tegmental area dopamine neurons to dopamine and ethanol
Gender differences in psychiatric disorders such as addiction may be modulated by the
steroid hormone estrogen. For instance, 17β-estradiol (E2), the predominant form of …
steroid hormone estrogen. For instance, 17β-estradiol (E2), the predominant form of …
Male and female rats differ in brain cannabinoid CB1 receptor density and function and in behavioural traits predisposing to drug addiction: effect of ovarian hormones
M Paola Castelli, P Fadda, A Casu… - Current …, 2014 - ingentaconnect.com
Sex-dependent differences are frequently observed in the biological and behavioural effects
of substances of abuse, including cannabis. We recently demonstrated a modulating effect …
of substances of abuse, including cannabis. We recently demonstrated a modulating effect …
Sex steroid hormones, the estrous cycle, and rapid modulation of glutamatergic synapse properties in the striatal brain regions with a focus on 17β-estradiol and the …
SB Proaño, CK Miller, AA Krentzel, DM Dorris… - Steroids, 2024 - Elsevier
The striatal brain regions encompassing the nucleus accumbens core (NAcc), shell (NAcs)
and caudate-putamen (CPu) regulate cognitive functions including motivated behaviors …
and caudate-putamen (CPu) regulate cognitive functions including motivated behaviors …
Estradiol mediates dendritic spine plasticity in the nucleus accumbens core through activation of mGluR5
BM Peterson, PG Mermelstein, RL Meisel - Brain Structure and Function, 2015 - Springer
Accumulating evidence from human and rodent studies suggests that females are more
sensitive to the motivating and rewarding properties of drugs of abuse. Numerous reports …
sensitive to the motivating and rewarding properties of drugs of abuse. Numerous reports …
Regulation of cocaine-related behaviours by estrogen and progesterone
Women are more sensitive to cocaine craving elicited by stimuli associated with relapse.
Ovarian hormones modulate cocaine craving and may therefore function as risk factors or …
Ovarian hormones modulate cocaine craving and may therefore function as risk factors or …
Sex differences in opioid analgesia and addiction: interactions among opioid receptors and estrogen receptors
CWS Lee, IK Ho - Molecular pain, 2013 - journals.sagepub.com
Opioids are widely used as the pain reliever and also notorious for being addictive drugs.
Sex differences in the opioid analgesia and addiction have been reported and investigated …
Sex differences in the opioid analgesia and addiction have been reported and investigated …
Estradiol modulates effort-based decision making in female rats
KA Uban, J Rummel, SB Floresco… - …, 2012 - nature.com
Disorders of the dopamine system, such as schizophrenia or stimulant addiction, are
associated with impairments in different forms of cost/benefit decision making. The neural …
associated with impairments in different forms of cost/benefit decision making. The neural …