Physiological functions of the β-site amyloid precursor protein cleaving enzyme 1 and 2
R Yan - Frontiers in molecular neuroscience, 2017 - frontiersin.org
BACE1 was discovered as the β-secretase for initiating the cleavage of amyloid precursor
protein (APP) at the β-secretase site, while its close homology BACE2 cleaves APP within …
protein (APP) at the β-secretase site, while its close homology BACE2 cleaves APP within …
The endolysosomal system and proteostasis: from development to degeneration
How do neurons adapt their endolysosomal system to address the particular challenge of
membrane transport across their elaborate cellular landscape and to maintain proteostasis …
membrane transport across their elaborate cellular landscape and to maintain proteostasis …
[HTML][HTML] VPS35 deficiency or mutation causes dopaminergic neuronal loss by impairing mitochondrial fusion and function
Summary Vacuolar protein sorting-35 (VPS35) is a retromer component for endosomal
trafficking. Mutations of VPS35 have been linked to familial Parkinson's disease (PD). Here …
trafficking. Mutations of VPS35 have been linked to familial Parkinson's disease (PD). Here …
VPS35 in dopamine neurons is required for endosome-to-Golgi retrieval of Lamp2a, a receptor of chaperone-mediated autophagy that is critical for α-synuclein …
Vacuolar protein sorting-35 (VPS35) is essential for endosome-to-Golgi retrieval of
membrane proteins. Mutations in the VPS35 gene have been identified in patients with …
membrane proteins. Mutations in the VPS35 gene have been identified in patients with …
Multi-omic approach characterises the neuroprotective role of retromer in regulating lysosomal health
JL Daly, CM Danson, PA Lewis, L Zhao… - Nature …, 2023 - nature.com
Retromer controls cellular homeostasis through regulating integral membrane protein
sorting and transport and by controlling maturation of the endo-lysosomal network. Retromer …
sorting and transport and by controlling maturation of the endo-lysosomal network. Retromer …
Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p. D620N
LN Munsie, AJ Milnerwood, P Seibler… - Human molecular …, 2015 - academic.oup.com
Abstract Vacuolar protein sorting 35 (VPS35) is a core component of the retromer complex,
crucial to endosomal protein sorting and intracellular trafficking. We recently linked a …
crucial to endosomal protein sorting and intracellular trafficking. We recently linked a …
Tau and other proteins found in Alzheimer's disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans
S Simoes, JL Neufeld, G Triana-Baltzer… - Science translational …, 2020 - science.org
Endosomal trafficking has emerged as a defective biological pathway in Alzheimer's disease
(AD), and the pathway is a source of cerebrospinal fluid (CSF) protein accumulation …
(AD), and the pathway is a source of cerebrospinal fluid (CSF) protein accumulation …
Endo-lysosomal pathway and ubiquitin-proteasome system dysfunction in Alzheimer's disease pathogenesis
Several lines of evidence have shown that defects in the endo-lysosomal autophagy
degradation pathway and the ubiquitin-proteasome system play a role in Alzheimer's …
degradation pathway and the ubiquitin-proteasome system play a role in Alzheimer's …
The retromer supports AMPA receptor trafficking during LTP
Alterations in the function of the retromer, a multisubunit protein complex that plays a
specialized role in endosomal sorting, have been linked to Alzheimer's and Parkinson's …
specialized role in endosomal sorting, have been linked to Alzheimer's and Parkinson's …
Neural stem cells in Parkinson's disease: a role for neurogenesis defects in onset and progression
JN Le Grand, L Gonzalez-Cano, MA Pavlou… - Cellular and Molecular …, 2015 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disorder, leading
to a variety of motor and non-motor symptoms. Interestingly, non-motor symptoms often …
to a variety of motor and non-motor symptoms. Interestingly, non-motor symptoms often …