Gastric cancer is one of the most common malignancies and remains the second leading
cause of cancer-related death worldwide. Over 70% of new cases and deaths occur in …

Secreted frizzled-related proteins (SFRP) are glycoproteins containing a so-called frizzled-
like cysteine-rich domain. This domain enables them to bind to Wnt ligands or frizzled (FzD) …

Gastric cancer is a heterogeneous cancer, making treatment responses difficult to predict.
Here we show that we identify two distinct molecular subtypes, mesenchymal phenotype …

Thymine DNA glycosylase (TDG) is a member of the uracil DNA glycosylase (UDG)
superfamily of DNA repair enzymes. Owing to its ability to excise thymine when mispaired …

Introduction: The Wnt/β-catenin signaling pathway plays a pivotal role in the regulation of
cell growth, cell development and the differentiation of normal stem cells. Constitutive …

Cancer initiation and progression is controlled by both genetic and epigenetic events.
Epigenetics refers to the study of mechanisms that alter gene expression without …

In light of the high incidence and mortality rates of cancer, early and accurate diagnosis is an
important priority for assigning optimal treatment for each individual with suspected illness …

BACKGROUND & AIMS: By using methylation-sensitive representational difference
analysis, we identified protocadherin 10 (PCDH10), a gene that encodes a protocadherin …

Secreted frizzled-related proteins (SFRPs) are mainly known for their role as extracellular
modulators and tumor suppressors that downregulate Wnt signaling. Using the established …

The Wnt signaling pathway is evolutionarily conserved, regulating both embryonic
development and maintaining adult tissue homeostasis. Wnt signaling controls several …