SARS-CoV-2-infection (COVID-19): clinical course, viral acute respiratory distress syndrome (ARDS) and cause (s) of death

GP Ramadori - Medical Sciences, 2022 - mdpi.com
SARS-CoV-2-infected symptomatic patients often suffer from high fever and loss of appetite
which are responsible for the deficit of fluids and of protein intake. Many patients admitted to …

Clinical sepsis phenotypes in critically ill patients

G Papathanakos, I Andrianopoulos, M Xenikakis… - Microorganisms, 2023 - mdpi.com
Sepsis, defined as the life-threatening dysregulated host response to an infection leading to
organ dysfunction, is considered as one of the leading causes of mortality worldwide …

Application of anti-inflammatory treatment in two different ovine acute respiratory distress syndrome injury models: a preclinical randomized intervention study

K Wildi, S Livingstone, C Ainola, SM Colombo… - Scientific Reports, 2023 - nature.com
Whilst the presence of 2 subphenotypes among the heterogenous Acute Respiratory
Distress Syndrome (ARDS) population is becoming clinically accepted, subphenotype …

A novel speckle‐tracking echocardiography parameter assessing left ventricular afterload

K Sato, K Wildi, J Chan, C Palmieri… - European Journal of …, 2024 - Wiley Online Library
Background Left ventricular stroke work index (LVSWI) and afterload‐related cardiac
performance (ACP) consider left ventricular (LV) afterload and could be better …

Failed clinical trials on COVID-19 acute respiratory distress syndrome in hospitalized patients: common oversights and streamlining the development of clinically …

D Battaglini, F Cruz, C Robba, P Pelosi… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction The coronavirus disease 2019 (COVID-19) pandemic has put a strain on global
healthcare systems. Despite admirable efforts to develop rapidly new pharmacotherapies …

An appraisal of lung computer tomography in very early anti-inflammatory treatment of two different ovine ARDS phenotypes

K Wildi, SM Colombo, D McGuire, C Ainola… - Scientific Reports, 2024 - nature.com
Mortality and morbidity of Acute Respiratory Distress Syndrome (ARDS) are largely
unaltered. A possible new approach to treatment of ARDS is offered by the discovery of …

Cardiovascular subphenotypes in ARDS: diagnostic and therapeutic implications and overlap with other ARDS subphenotypes

M Chotalia, JM Patel, MN Bangash… - Journal of Clinical …, 2023 - mdpi.com
Acute respiratory distress syndrome (ARDS) is a highly heterogeneous clinical condition.
Shock is a poor prognostic sign in ARDS, and heterogeneity in its pathophysiology may be a …

[HTML][HTML] Donor heart ischemic time can be extended beyond 9 hours using hypothermic machine perfusion in sheep

LES Hoe, GL Bassi, K Wildi, MR Passmore… - The Journal of Heart and …, 2023 - Elsevier
Background The global shortage of donor hearts available for transplantation is a major
problem for the treatment of end-stage heart failure. The ischemic time for donor hearts …

Biological basis of critical illness subclasses: from the bedside to the bench and back again

J Stevens, O Tezel, V Bonnefil, M Hapstack, MR Atreya - Critical Care, 2024 - Springer
Critical illness syndromes including sepsis, acute respiratory distress syndrome, and acute
kidney injury (AKI) are associated with high in-hospital mortality and long-term adverse …

Treatment for acute respiratory distress syndrome in adults: a narrative review of phase 2 and 3 trials

D Battaglini, C Robba, P Pelosi… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Ventilatory management and general supportive care of acute respiratory
distress syndrome (ARDS) in the adult population have led to significant clinical …