Methamphetamine (METH) is a powerful central nervous system stimulant which elevates mood, alertness, energy levels and concentration in the short-term. However, chronic use …
Psychedelic drugs, such as lysergic acid diethylamide (LSD), mescaline, and psilocybin, exert profound effects on brain and behavior. After decades of difficulties in studying these …
Biogenic amines are a collection of endogenous molecules that play pivotal roles as neurotransmitters and hormones. In addition to the “classical” biogenic amines resulting …
All antipsychotics currently used in clinic block D2 dopamine receptors. Trace amine- associated receptor 1 is emerging as a new therapeutic target for schizophrenia and several …
L Yang, L Zhang, H Zhang, J Liu - Meta-Radiology, 2023 - Elsevier
Substance use disorder (SUD) is a type of addictive encephalopathy resulting from drug abuse, which leads to abnormal cerebral alterations indicating neurotoxicity that is …
G D'Andrea, G Pizzolato, A Gucciardi, M Stocchero… - Scientific Reports, 2019 - nature.com
Early diagnosis of Parkinson's disease (PD) remains a challenge to date. New evidence highlights the potential clinical value of circulating trace amines (TAs) in early-stage PD and …
3-Iodothyronamine (T1AM) is an endogenous high-affinity ligand of the trace amine- associated receptor 1 (TAAR1), detected in mammals in many organs, including the brain …
A Vattai, E Akyol, C Kuhn, S Hofmann… - Journal of cancer …, 2017 - Springer
Purpose A correlation between breast cancer and thyroid disorders has been described in previous studies. Degraded thyroid hormones are referred to as trace amines. These …
G Galley, A Beurier, G Décoret, A Goergler… - ACS medicinal …, 2016 - ACS Publications
2-Aminooxazolines were discovered as a novel structural class of TAAR1 ligands. Starting from a known adrenergic compound 1, structural modifications were made to obtain highly …