Trace amines and their receptors

RR Gainetdinov, MC Hoener, MD Berry… - Pharmacological …, 2018 - Elsevier
Trace amines are endogenous compounds classically regarded as comprising β-
phenylethyalmine, p-tyramine, tryptamine, p-octopamine, and some of their metabolites …

Methamphetamine: effects on the brain, gut and immune system

MD Prakash, K Tangalakis, J Antonipillai… - Pharmacological …, 2017 - Elsevier
Methamphetamine (METH) is a powerful central nervous system stimulant which elevates
mood, alertness, energy levels and concentration in the short-term. However, chronic use …

Psychedelic drugs in biomedicine

EJ Kyzar, CD Nichols, RR Gainetdinov… - Trends in …, 2017 - cell.com
Psychedelic drugs, such as lysergic acid diethylamide (LSD), mescaline, and psilocybin,
exert profound effects on brain and behavior. After decades of difficulties in studying these …

Trace amines and the trace amine-associated receptor 1: pharmacology, neurochemistry, and clinical implications

Y Pei, A Asif-Malik, JJ Canales - Frontiers in neuroscience, 2016 - frontiersin.org
Biogenic amines are a collection of endogenous molecules that play pivotal roles as
neurotransmitters and hormones. In addition to the “classical” biogenic amines resulting …

Unlocking the therapeutic potential of ulotaront as a trace amine-associated receptor 1 agonist for neuropsychiatric disorders

SR Kuvarzin, I Sukhanov, K Onokhin, K Zakharov… - Biomedicines, 2023 - mdpi.com
All antipsychotics currently used in clinic block D2 dopamine receptors. Trace amine-
associated receptor 1 is emerging as a new therapeutic target for schizophrenia and several …

[HTML][HTML] Application of omics-based biomarkers in substance use disorders

L Yang, L Zhang, H Zhang, J Liu - Meta-Radiology, 2023 - Elsevier
Substance use disorder (SUD) is a type of addictive encephalopathy resulting from drug
abuse, which leads to abnormal cerebral alterations indicating neurotoxicity that is …

Different Circulating Trace Amine Profiles in De Novo and Treated Parkinson's Disease Patients

G D'Andrea, G Pizzolato, A Gucciardi, M Stocchero… - Scientific Reports, 2019 - nature.com
Early diagnosis of Parkinson's disease (PD) remains a challenge to date. New evidence
highlights the potential clinical value of circulating trace amines (TAs) in early-stage PD and …

New insights into the potential roles of 3-iodothyronamine (T1AM) and newly developed thyronamine-like TAAR1 agonists in neuroprotection

L Bellusci, A Laurino, M Sabatini, S Sestito… - Frontiers in …, 2017 - frontiersin.org
3-Iodothyronamine (T1AM) is an endogenous high-affinity ligand of the trace amine-
associated receptor 1 (TAAR1), detected in mammals in many organs, including the brain …

Increased trace amine-associated receptor 1 (TAAR1) expression is associated with a positive survival rate in patients with breast cancer

A Vattai, E Akyol, C Kuhn, S Hofmann… - Journal of cancer …, 2017 - Springer
Purpose A correlation between breast cancer and thyroid disorders has been described in
previous studies. Degraded thyroid hormones are referred to as trace amines. These …

Discovery and characterization of 2-aminooxazolines as highly potent, selective, and orally active TAAR1 agonists

G Galley, A Beurier, G Décoret, A Goergler… - ACS medicinal …, 2016 - ACS Publications
2-Aminooxazolines were discovered as a novel structural class of TAAR1 ligands. Starting
from a known adrenergic compound 1, structural modifications were made to obtain highly …