The coronavirus disease 2019 (COVID-19) became a worldwide concern at the beginning of
2020 and has affected millions. Several previous studies revealed the impact of the …

SARS-CoV-2 causes the complex and heterogeneous illness known as COVID-19. The
disease primarily affects the respiratory system but can quickly become systemic, harming …

The Orthopoxvirus (OPXV) genus of the Poxviridae includes human pathogens variola virus
(VARV), monkeypox virus (MPXV), vaccinia virus (VACV), and a number of zoonotic viruses …

Coronavirus endoribonuclease Nsp15 contributes to the evasion of host innate immunity by
suppressing levels of viral dsRNA. Nsp15 cleaves both ssRNA and dsRNA in vitro with a …

The SARS-CoV-2 genome encodes a multitude of accessory proteins. Using comparative
genomic approaches, an additional accessory protein, ORF3c, has been predicted to be …

Coronavirus disease 19 is caused by severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) enveloped virus with a single-stranded positive-sense ribonucleic acid …

Human tripartite motif protein 5α (TRIM5α) is a well-characterized restriction factor for some
RNA viruses, including HIV,,,–; however, reports are limited for DNA viruses,. Here we …

The SARS-CoV-2 pandemic persists with global repercussions. Initial COVID-19 symptoms
encompass pneumonia, fever, myalgia, and fatigue. The human immune system produces …

The ORF6 protein of the SARS-CoV-2 virus plays a crucial role in blocking the innate
immune response of the infected cells by inhibiting interferon pathways. Additionally, it binds …

Innate immune response is the first line of defense for the host against virus invasion. One
important response is the synthesis and secretion of type I interferon (IFN-I) in the virus …