The complement system was discovered at the end of the 19th century as a heat-labile
plasma component that “complemented” the antibodies in killing microbes, hence the name …

The complement system comprises several fluid-phase and membrane-associated proteins.
Under physiological conditions, activation of the fluid-phase components of complement is …

A major function of the immune system is to protect the host from microbial infections. The
complement system plays important roles in both the innate and the adaptive immune …

Mannose-binding lectin (MBL) and lectin complement pathway have become targets of
increasing clinical interest. Many aspects of MBL have been recently explored, including the …

Recurrent vulvovaginal infections (RVVI), a devastating group of mucosal infection, are
severely affecting women's quality of life. Our understanding of the vaginal defense …

Mannose-binding lectin (MBL) targets diverse microorganisms for phagocytosis and
complement-mediated lysis by binding specific surface glycans. Although recombinant …

Maintenance of homeostasis at body barriers that are constantly challenged by microbes,
toxins and potentially bioactive (macro) molecules requires complex, highly orchestrated …

Severe sepsis and septic shock are a primary cause of death in patients in intensive care
unit (ICU). Investigations upon genetic susceptibility profile to systemic complications during …

The role of mannose-binding lectin (MBL) deficiency (MBL2; XA/O and O/O genotypes) in
host defences remains controversial. The surfactant proteins (SP)-A1,-A2 and-D, other …

MBL-deficiency is a commonly occurring deficiency of the innate immune system, affecting a
substantial part of the population and has been extensively studied. MBL appears to function …