Immune-based therapies such as immune checkpoint inhibitors have revolutionized the
systemic treatment of various cancer types. The therapeutic application of monoclonal …

Basic science breakthroughs in T-cell biology and immune–tumor cell interactions ushered
in a new era of cancer immunotherapy. Twenty years ago, cancer immunoediting was …

The advent of immunotherapy has made an indelible mark on the field of cancer therapy,
especially the application of immune checkpoint inhibitors in clinical practice. Although …

Incapacitated immune system is a characteristic hallmark of solid tumors. Immune system
within a tumor undergoes an imbalance in cellular dispersion and functionality. Effector cells …

Immunity is shaped by commensal microbiota. From early life onwards, microbes colonize
mucosal surfaces of the body and thereby trigger the establishment of immune homeostasis …

Group 2 innate lymphoid cells (ILC2s) are abundant in non-lymphoid tissues and increase
following infectious and inflammatory insults. In solid tumors, however, ILC2s constitute a …

Immune checkpoint inhibitor (ICI) therapy has caused a paradigm shift in cancer therapeutic
strategy. However, this therapy only benefits a subset of patients. The difference in …

Circulating leukocytes are an important part of the immune system. The aim of this work is to
explore the role of preoperative circulating leukocytes in serous ovarian carcinoma and …

Abstract Background Tumor-associated macrophages (TAMs) are an important subset of
innate immune cells in the tumor microenvironment, and they are pivotal regulators of tumor …

Our understanding of type 2 immunity has undergone a substantial transformation in recent
years, revealing previously unknown functions. Beyond its canonical role in defence against …