Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …

Cardiovascular diseases are the leading cause of death worldwide. Overweight and obesity
are strongly associated with comorbidities such as hypertension and insulin resistance …

Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy
in the form of heat. These thermogenic fat cells were originally considered to function solely …

Over the past decade, great progress has been made in understanding the complexity of
adipose tissue biology and its role in metabolism. This includes new insights into the …

Adipose tissue not only has an important role in the storage of excess nutrients but also
senses nutrient status and regulates energy mobilization. An overall positive energy balance …

BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for
the treatment of overactive bladder. Encouraging preclinical results suggest that β3-AR …

Adipose tissues dynamically remodel their cellular composition in response to external cues
by stimulating beige adipocyte biogenesis; however, the developmental origin and …

Two types of thermogenic fat cells, brown adipocytes and beige adipocytes, play a key role
in the regulation of systemic energy homeostasis in mammals. Both brown fat and beige fat …

Human brown adipose tissue (BAT) can be activated to increase glucose uptake and energy
expenditure, making it a potential target for treating obesity and metabolic disease. Data on …

White adipose tissue (WAT) is an endocrine organ highly integrated in homeostasis and
capable of establishing ways of communicating and influencing multiple metabolic …