Bioluminescent and chemiluminescent probes are widely used for noninvasive imaging
applications because of their high sensitivity and the simplicity of the equipment required to …

Chemiluminescence (CL) and bioluminescence (BL) imaging technologies, which require
no external light source so as to avoid the photobleaching, background interference and …

In recent years, in vitro transcribed messenger RNA (mRNA) has emerged as a potential
therapeutic platform. To fulfill its promise, effective delivery of mRNA to specific cell types …

Bioluminescence is found across the entire tree of life, conferring a spectacular set of
visually oriented functions from attracting mates to scaring off predators. Half a dozen …

Red-shifted bioluminescence reporters are desirable for biological imaging. We describe the
development of red-shifted luciferins based on synthetic coelenterazine analogs and …

With the ability to noninvasively image and monitor molecular processes within tumors,
molecular imaging represents a fundamental tool for cancer scientists. In the current review …

Multicomponent bioluminescence imaging in vivo requires an expanded collection of tissue-
penetrant probes. Toward this end, we generated a new class of near-infrared (NIR) emitting …

Iron is an essential metal for all organisms, yet disruption of its homeostasis, particularly in
labile forms that can contribute to oxidative stress, is connected to diseases ranging from …

Red‐shifted bioluminescent emitters allow improved in vivo tissue penetration and signal
quantification, and have led to the development of beetle luciferin analogues that elicit red …

Firefly luciferase adenylates and oxidizes d-luciferin to chemically generate visible light and
is widely used for biological assays and imaging. Here we show that both luciferase and …