Infections of antibiotic-resistant pathogens pose an ever-increasing threat to mankind. The
investigation of novel approaches for tackling the antimicrobial resistance crisis must be part …

The growing number of bacterial pathogens that are resistant to numerous antibiotics is a
cause for concern around the globe. There have been no new broad‐spectrum antibiotics …

Proteasome inhibitors have revolutionized the treatment of multiple myeloma, and validated
the therapeutic potential of the ubiquitin proteasome system (UPS). It is believed that in part …

Pyridazine derivatives are privileged structures because of their potential biological and
optical properties. Traditional synthetic methods usually require acid or base as a catalyst …

The first total syntheses of the natural products lobaric acid (1) and its derivatives isolated
from the Antarctic lichen Stereocaulon alpinum are reported in this study. Lobarin (3), with a …

Aberrant protein citrullination is associated with many pathologies; however, the specific
effects of this modification remain unknown. We have previously demonstrated that serine …

To counter the emergence of β-lactamase (BL) mediated resistance, design of new β-
lactamase inhibitors (BLIs) is critical. Many high-resolution crystallographic structures of BL …

A general and efficient synthesis of the 2 H-tetrahydro-4, 6-dioxo-1, 2-oxazine ring system
through a tandem nucleophilic addition and transesterification reaction is described. The …

The N, O-diacylhydroxylamine derivative 4 has been prepared and its reactivity with
nucleophiles investigated. On reaction with lithium enolates of cyclic or acyclic ketones, 4 is …

Abstract The 2H‐tetrahydro‐4, 6‐dioxo‐1, 2‐oxazine (TDO) ring, a rare structural motif
embedded in the molecular architecture of alchivemycins, is synthesized from 2, 2, 6 …