The significant other: splicing by the minor spliceosome
The removal of non‐coding sequences, introns, from the mRNA precursors is an essential
step in eukaryotic gene expression. U12‐type introns are a minor subgroup of introns …
step in eukaryotic gene expression. U12‐type introns are a minor subgroup of introns …
Splicing double: insights from the second spliceosome
AA Patel, JA Steitz - Nature reviews Molecular cell biology, 2003 - nature.com
The genomes of most multicellular organisms contain a new class of introns that have non-
canonical consensus sequences. These minor-class introns occur extremely rarely and are …
canonical consensus sequences. These minor-class introns occur extremely rarely and are …
Prp8 protein: at the heart of the spliceosome
RJ Grainger, JD Beggs - Rna, 2005 - rnajournal.cshlp.org
Pre-messenger RNA (pre-mRNA) splicing is a central step in gene expression. Lying
between transcription and protein synthesis, pre-mRNA splicing removes sequences …
between transcription and protein synthesis, pre-mRNA splicing removes sequences …
[HTML][HTML] Structural studies of the spliceosome: bridging the gaps
The spliceosome is a multi-megadalton RNA–protein complex responsible for the removal of
non-coding introns from pre-mRNAs. Due to its complexity and dynamic nature, it has …
non-coding introns from pre-mRNAs. Due to its complexity and dynamic nature, it has …
Structure of the activated human minor spliceosome
INTRODUCTION Precursor messenger RNA (pre-mRNA) splicing, which involves the
removal of noncoding introns and the ligation of the coding exons, is achieved by the …
removal of noncoding introns and the ligation of the coding exons, is achieved by the …
New connections between splicing and human disease
RA Padgett - Trends in Genetics, 2012 - cell.com
The removal by splicing of introns from the primary transcripts of most mammalian genes is
an essential step in gene expression. Splicing is performed by large, complex …
an essential step in gene expression. Splicing is performed by large, complex …
Haploinsufficiency of a spliceosomal GTPase encoded by EFTUD2 causes mandibulofacial dysostosis with microcephaly
MA Lines, L Huang, J Schwartzentruber… - The American Journal of …, 2012 - cell.com
Mandibulofacial dysostosis with microcephaly (MFDM) is a rare sporadic syndrome
comprising craniofacial malformations, microcephaly, developmental delay, and a …
comprising craniofacial malformations, microcephaly, developmental delay, and a …
The life of U6 small nuclear RNA, from cradle to grave
AL Didychuk, SE Butcher, DA Brow - Rna, 2018 - rnajournal.cshlp.org
Removal of introns from precursor messenger RNA (pre-mRNA) and some noncoding
transcripts is an essential step in eukaryotic gene expression. In the nucleus, this process of …
transcripts is an essential step in eukaryotic gene expression. In the nucleus, this process of …
[HTML][HTML] Minor spliceosome and disease
B Verma, MV Akinyi, AJ Norppa, MJ Frilander - Seminars in cell & …, 2018 - Elsevier
Abstract The U12-dependent (minor) spliceosome excises a rare group of introns that are
characterized by a highly conserved 5′ splice site and branch point sequence. Several …
characterized by a highly conserved 5′ splice site and branch point sequence. Several …
Complex spliceosomal organization ancestral to extant eukaryotes
L Collins, D Penny - Molecular biology and evolution, 2005 - academic.oup.com
In higher eukaryotes, introns are spliced out of protein-coding mRNAs by the spliceosome, a
massive complex comprising five non-coding RNAs (ncRNAs) and about 200 proteins. By …
massive complex comprising five non-coding RNAs (ncRNAs) and about 200 proteins. By …