The gut–joint axis in rheumatoid arthritis

MM Zaiss, HJ Joyce Wu, D Mauro, G Schett… - Nature Reviews …, 2021 - nature.com
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder that primarily
affects the joints. One hypothesis for the pathogenesis of RA is that disease begins at …

Gut microbiota and rheumatoid arthritis: From pathogenesis to novel therapeutic opportunities

T Zhao, Y Wei, Y Zhu, Z Xie, Q Hai, Z Li… - Frontiers in …, 2022 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects the joints.
Microbial infection is considered a crucial inducer of RA. Alterations in the composition of …

The microbiome in autoimmune diseases

F De Luca, Y Shoenfeld - Clinical & Experimental Immunology, 2019 - academic.oup.com
The microbiome is represented by microorganisms which live in a symbiotic way with the
mammalian. Microorganisms have the ability to influence different physiological aspects …

An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis

J Chen, K Wright, JM Davis, P Jeraldo, EV Marietta… - Genome medicine, 2016 - Springer
Background The adaptive immune response in rheumatoid arthritis (RA) is influenced by an
interaction between host genetics and environment, particularly the host microbiome …

The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting

V Malmström, AI Catrina, L Klareskog - Nature Reviews Immunology, 2017 - nature.com
Patients with rheumatoid arthritis can be divided into two major subsets characterized by the
presence versus absence of antibodies to citrullinated protein antigens (ACPAs) and of …

Age-and sex-dependent patterns of gut microbial diversity in human adults

J de la Cuesta-Zuluaga, ST Kelley, Y Chen… - Msystems, 2019 - Am Soc Microbiol
Gut microbial diversity changes throughout the human life span and is known to be
associated with host sex. We investigated the association of age, sex, and gut bacterial …

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

JU Scher, A Sczesnak, RS Longman, N Segata… - elife, 2013 - elifesciences.org
Rheumatoid arthritis (RA) is a prevalent systemic autoimmune disease, caused by a
combination of genetic and environmental factors. Animal models suggest a role for …

Intestinal dysbiosis and rheumatoid arthritis: a link between gut microbiota and the pathogenesis of rheumatoid arthritis

G Horta-Baas, MS Romero-Figueroa… - Journal of …, 2017 - Wiley Online Library
Characterization and understanding of gut microbiota has recently increased representing a
wide research field, especially in autoimmune diseases. Gut microbiota is the major source …

Intestinal dysbiosis and probiotic applications in autoimmune diseases

GLV de Oliveira, AZ Leite, BS Higuchi… - …, 2017 - Wiley Online Library
In humans, a complex interaction between the host immune system and commensal
microbiota is required to maintain gut homeostasis. In this symbiotic relationship, the …

Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design

D Laukens, BM Brinkman, J Raes… - FEMS microbiology …, 2016 - academic.oup.com
Targeted manipulation of the gut flora is increasingly being recognized as a means to
improve human health. Yet, the temporal dynamics and intra-and interindividual …