Integrative approaches to understand the mastery in manipulation of host cytokine networks by protozoan parasites with emphasis on Plasmodium and Leishmania …

A Mahanta, P Ganguli, P Barah, RR Sarkar… - Frontiers in …, 2018 - frontiersin.org
Diseases by protozoan pathogens pose a significant public health concern, particularly in
tropical and subtropical countries, where these are responsible for significant morbidity and …

Correlation between inflammatory biomarkers and red blood cell life span in chronic hemodialysis patients

J Ma, Y Dou, H Zhang, S Thijssen, S Williams… - Blood purification, 2017 - karger.com
Abstract Background and Objectives: The pathogenesis of anemia in hemodialysis (HD)
patients is dependent on multiple factors, with decreased red blood cell life span (RBCLS) …

Acute Plasmodium berghei Mouse Infection Elicits Perturbed Erythropoiesis With Features That Overlap With Anemia of Chronic Disease

A Lakkavaram, RJ Lundie, H Do, AC Ward… - Frontiers in …, 2020 - frontiersin.org
Severe malaria anemia is one of the most common causes of morbidity and mortality arising
from infection with Plasmodium falciparum. The pathogenesis of malarial anemia is …

Heightened inflammation in severe malaria is associated with decreased IL-10 expression levels and neutrophils

A Mahanta, SK Kar, S Kakati, S Baruah - Innate immunity, 2015 - journals.sagepub.com
Dysregulation of the cytokine network in severe malaria owing to variations in factors like
parasite load, strains and host factors is well documented but the key cytokines that are …

Integrated OMICS platforms identify LAIR1 genetic variants as novel predictors of cross-sectional and longitudinal susceptibility to severe malaria and all-cause …

AO Achieng, NW Hengartner, E Raballah, Q Cheng… - …, 2019 - thelancet.com
Background Severe malarial anaemia (SMA) is a leading cause of childhood mortality in
holoendemic Plasmodium falciparum regions. Methods To gain an improved understanding …

[HTML][HTML] Transcriptomic and Proteomic Insights into Host Immune Responses in Pediatric Severe Malarial Anemia: Dysregulation in HSP60-70-TLR2/4 Signaling and …

CO Onyango, SB Anyona, I Hurwitz, E Raballah… - Pathogens, 2024 - mdpi.com
Severe malarial anemia (SMA, Hb< 6.0 g/dL) is a leading cause of childhood morbidity and
mortality in holoendemic Plasmodium falciparum transmission zones. This study explored …

IL18 Gene Variants Influence the Susceptibility to Chagas Disease

DA Leon Rodriguez, FD Carmona… - PLoS neglected …, 2016 - journals.plos.org
Chagas disease is a parasitic disorder caused by the infection with the flagellated protozoan
Trypanosoma cruzi. According to the World Health Organization, more than six million …

Contribution of inflammasome genetics in Plasmodium vivax malaria

MLS Santos, EC Reis, PN Bricher, TN Sousa… - Infection, Genetics and …, 2016 - Elsevier
Recent reports showed that, in mice, symptomatic Plasmodium infection triggers
NLRP3/NLRP12-dependent inflammasome formation and caspase-1 activation in …

Reduced interferon (IFN)-α conditioned by IFNA2 (−173) and IFNA8 (−884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and …

P Kempaiah, SB Anyona, E Raballah, GC Davenport… - Human genetics, 2012 - Springer
Severe malarial anemia (SMA) is a leading cause of pediatric morbidity and mortality in
holoendemic Plasmodium falciparum transmission areas. Although dysregulation in …

[HTML][HTML] CCL3L1 copy number and susceptibility to malaria

D Carpenter, A Färnert, I Rooth, JAL Armour… - Infection, Genetics and …, 2012 - Elsevier
Copy number variation can contribute to the variation observed in susceptibility to complex
diseases. Here we present the first study to investigate copy number variation of the …