Pathophysiology and pathology of acute kidney injury in patients with COVID-19

JH Ng, V Bijol, MA Sparks, ME Sise, H Izzedine… - Advances in Chronic …, 2020 - Elsevier
Acute kidney injury (AKI) is common among hospitalized patients with Coronavirus
Infectious Disease 2019 (COVID-19), with the occurrence of AKI ranging from 0.5% to 80 …

[HTML][HTML] Podocytes

J Reiser, MM Altintas - F1000Research, 2016 - ncbi.nlm.nih.gov
Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries
and that neighbor cells of the Bowman's capsule. When it comes to glomerular filtration …

[HTML][HTML] Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1

B Nichols, P Jog, JH Lee, D Blackler, M Wilmot… - Kidney international, 2015 - Elsevier
Apolipoprotein L1 (APOL1) risk variants greatly elevate the risk of kidney disease in African
Americans. Here we report a cohort of patients who developed collapsing focal segmental …

ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption

S Ashraf, HY Gee, S Woerner, LX Xie… - The Journal of …, 2013 - Am Soc Clin Investig
Identification of single-gene causes of steroid-resistant nephrotic syndrome (SRNS) has
furthered the understanding of the pathogenesis of this disease. Here, using a combination …

[HTML][HTML] PIK3CA inhibition in models of proliferative glomerulonephritis and lupus nephritis

J Yamaguchi, P Isnard, N Robil, P de la Grange… - The Journal of Clinical …, 2024 - jci.org
Proliferative glomerulonephritis is a severe condition that often leads to kidney failure. There
is a significant lack of effective treatment for these disorders. Here, following the …

A proposed taxonomy for the podocytopathies: a reassessment of the primary nephrotic diseases

L Barisoni, HW Schnaper, JB Kopp - Clinical Journal of the …, 2007 - journals.lww.com
A spectrum of proteinuric glomerular diseases results from podocyte abnormalities. The
understanding of these podocytopathies has greatly expanded in recent years, particularly …

Apolipoprotein L1 risk variants associate with systemic lupus erythematosus-associated collapsing glomerulopathy

CP Larsen, ML Beggs, M Saeed… - Journal of the American …, 2013 - journals.lww.com
Collapsing glomerulopathy is a devastating renal disease that primarily affects African
Americans and associates with numerous etiologies, such as HIV and autoimmune disease …

Treatment with IFN-α,-β, or-γ is associated with collapsing focal segmental glomerulosclerosis

GS Markowitz, SH Nasr, MB Stokes… - Clinical Journal of the …, 2010 - journals.lww.com
Treatment with IFN-α, -β, or -γ Is Associated with Collapsin... : Clinical Journal of the American
Society of Nephrology Treatment with IFN-α, -β, or -γ Is Associated with Collapsing Focal …

[HTML][HTML] COVID-19–associated collapsing focal segmental glomerulosclerosis: a report of 2 cases

Y Sharma, SH Nasr, CP Larsen, A Kemper, AH Ormsby… - Kidney medicine, 2020 - Elsevier
Collapsing glomerulopathy is an aggressive form of focal segmental glomerulosclerosis with
diverse causes. The presence of the apolipoprotein L1 (APOL1) high-risk genotype is a …

Renal progenitor cells contribute to hyperplastic lesions of podocytopathies and crescentic glomerulonephritis

B Smeets, ML Angelotti, P Rizzo… - Journal of the …, 2009 - journals.lww.com
Glomerular injury can involve excessive proliferation of glomerular epithelial cells, resulting
in crescent formation and obliteration of Bowman's space. The origin of these hyperplastic …