The amygdala has long been associated with emotion and motivation, playing an essential
part in processing both fearful and rewarding environmental stimuli. How can a single …

Although anxiety disorders represent a major societal problem demanding new therapeutic
targets, these efforts have languished in the absence of a mechanistic understanding of this …

Central regulation of food intake is a key mechanism contributing to energy homeostasis.
Many neural circuits that are thought to orchestrate feeding behavior overlap with the brain's …

“A rigorous, in-depth guide to the history, philosophy, and scientific exploration of this
widespread emotional state...[LeDoux] offers a magisterial review of the role of mind and …

The consequences of chronic stress on brain structure and function are far reaching.
Whereas stress can produce short-term adaptive changes in the brain, chronic stress leads …

Sophisticated behavioral paradigms partnered with the emergence of increasingly selective
techniques to target the basolateral amygdala (BLA) have resulted in an enhanced …

Behavioral choice is ubiquitous in the animal kingdom and is central to goal-oriented
behavior. Hypothalamic Agouti-related peptide (AgRP) neurons are critical regulators of …

The central extended amygdala is an evolutionarily conserved set of interconnected brain
regions that play an important role in threat processing to promote survival. Two core …

Impaired function in the medial prefrontal cortex (mPFC) contributes to depression, and the
therapeutic response produced by novel rapid-acting antidepressants such as ketamine are …

Given the strong evidence for neurological alterations at the basis of drug dependence,
functional magnetic resonance imaging (fMRI) represents an important tool in the clinical …