[HTML][HTML] Spontaneous HIT syndrome: knee replacement, infection, and parallels with vaccine-induced immune thrombotic thrombocytopenia

TE Warkentin, A Greinacher - Thrombosis Research, 2021 - Elsevier
Heparin-induced thrombocytopenia (HIT) is characterized clinically by thrombocytopenia,
hypercoagulability, and increased thrombosis risk, and serologically by platelet-activating …

COVID-19 versus HIT hypercoagulability

TE Warkentin, S Kaatz - Thrombosis research, 2020 - Elsevier
A striking feature of COVID-19 is the high frequency of thrombosis, particularly in patients
who require admission to intensive care unit because of respiratory complications …

The temporal profile of the anti-PF4/heparin immune response

A Greinacher, T Kohlmann, U Strobel… - Blood, The Journal …, 2009 - ashpublications.org
The immune response in heparin-induced thrombocytopenia (HIT) is puzzling: heparin-
naive patients can develop IgG antibodies and clinical HIT as early as day 5, and evidence …

Heparin-induced thrombocytopenia in patients with ventricular assist devices: are new prevention strategies required?

TE Warkentin, A Greinacher, A Koster - The Annals of thoracic surgery, 2009 - Elsevier
Heparin-induced thrombocytopenia (HIT) is caused by platelet-activating antiplatelet factor
4/heparin antibodies. However, clinical HIT (thrombocytopenia or thrombosis, or both) …

A diagnosis of heparin-induced thrombocytopenia with combined clinical and laboratory methods in cardiothoracic surgical intensive care unit patients

LJ Demma, AM Winkler, JH Levy - Anesthesia & Analgesia, 2011 - journals.lww.com
BACKGROUND: Diagnosing postoperative heparin-induced thrombocytopenia (HIT) in
cardiothoracic surgical patients is complicated because of the profound thrombocytopenia …

Mechanical prophylaxis is a heparin-independent risk for anti–platelet factor 4/heparin antibody formation after orthopedic surgery

S Bito, S Miyata, K Migita, M Nakamura… - Blood, The Journal …, 2016 - ashpublications.org
Platelet-activating antibodies, which recognize platelet factor 4 (PF4)/heparin complexes,
induce spontaneous heparin-induced thrombocytopenia (HIT) syndrome or fondaparinux …

The unique immunological features of heparin‐induced thrombocytopenia

P Staibano, DM Arnold… - British Journal of …, 2017 - Wiley Online Library
Heparin‐induced thrombocytopenia (HIT) is a serious drug reaction that leads to a decrease
in platelet count and a high risk of thrombosis. HIT patients produce pathogenic …

Outcomes with heparin-induced thrombocytopenia after cardiac surgery

JA Brown, E Aranda-Michel, A Kilic… - The Annals of Thoracic …, 2021 - Elsevier
Background Heparin-induced thrombocytopenia (HIT) is an immune-mediated reaction to
heparin that provokes a prothrombotic state and causes a decline in platelet count. Data …

[HTML][HTML] Is COVID-19 an independent risk factor for heparin-induced thrombocytopenia?

S Madala, M Krzyzak, S Dehghani - Cureus, 2021 - ncbi.nlm.nih.gov
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a viral respiratory
illness initially described in Wuhan, China, and was declared a pandemic by World Health …

Incidence and clinical relevance of anti–platelet factor 4/heparin antibodies before cardiac surgery

S Selleng, B Malowsky, T Itterman, J Bagemühl… - American heart …, 2010 - Elsevier
BACKGROUND: Heparin-induced thrombocytopenia (HIT) is caused by anti–platelet factor
4/heparin (PF4/H) immunoglobulin (Ig) G antibodies, which activate platelets. In some …