Nuciferine aporphine alkaloid mainly exists in Nelumbo nucifera Gaertn and is a beneficial
to human health, such as anti-obesity, lowering blood lipid, prevention of diabetes and …

Liver cancer is the second most frequent cause of cancer-related death globally. The main
histological subtype is hepatocellular carcinoma (HCC), which is derived from hepatocytes …

Background Autophagic flux is coordinated by a network of master regulatory genes, which
centered on transcription factor EB (TFEB). The disorders of autophagic flux are closely …

Diallyl disulfide (DADS) has been suggested to possess hepatoprotection against alcoholic
liver disease (ALD) by a couple of pilot studies, while the underlying mechanisms remain …

Aldehyde dehydrogenase 2 (ALDH2) has both dehydrogenase and esterase activity; its
dehydrogenase activity is closely related to the metabolism of aldehydes produced under …

Fucoxanthin (Fx) is a natural extract from marine seaweed that has strong antioxidant activity
and a variety of other bioactive effects. This study elucidated the protective mechanism of Fx …

Depression is a prevalent psychiatric disorder and a leading cause of disability worldwide.
Despite a variety of available treatments currently being used in the clinic, a substantial …

Gut microbiota dysbiosis has been a crucial contributor to the pathogenesis of alcoholic fatty
liver disease (AFLD). Tea is a popular beverage worldwide and exerts antioxidant and anti …

Hederagenin (HG) is a pentacyclic triterpenoid that exists in many plants in the form (s) of
sapogenin or saponins. This review highlights the pharmacokinetics, pharmacological …

Background Acute kidney injury (AKI), a kidney disease with high morbidity and mortality, is
characterized by a dramatic decline in renal function. Hederagenin (HDG), a pentacyclic …