Cell shape changes underlie a large set of biological processes ranging from cell division to
cell motility. Stereotyped patterns of cell shape changes also determine tissue remodeling …

Formin proteins were recognized as effectors of Rho GTPases some 15 years ago. They
contribute to different cellular actin cytoskeleton structures by their ability to polymerize …

Formins are highly conserved proteins that have essential roles in remodelling the actin and
microtubule cytoskeletons to influence eukaryotic cell shape and behaviour. Recent work …

Formins are conserved actin polymerization machines that have instrumental roles in
controlling rearrangements of the actin cytoskeleton and have recently been shown to …

Microtubules (MTs) govern actin network remodeling in a wide range of biological
processes, yet the mechanisms underlying this cytoskeletal cross-talk have remained …

Cells precisely control the formation of dynamic actin cytoskeleton networks to coordinate
fundamental processes, including motility, division, endocytosis and polarization. To support …

Gene duplication is a fundamental process in genome evolution. However, most young
duplicates are degraded by loss-of-function mutations, and the factors that allow some …

The GTPase Cdc42 regulates polarized growth in most eukaryotes. In the bipolar yeast
Schizosaccharomyces pombe, Cdc42 activation cycles periodically at sites of polarized …

One kind of the most extremely polarized cells in nature are the indefinitely growing hyphae
of filamentous fungi. A continuous flow of secretion vesicles from the hyphal cell body to the …

The dynamic activity of tip-localized filamentous actin (F-actin) in pollen tubes is controlled
by counteracting RIC4 and RIC3 pathways downstream of the ROP1 guanosine …