Wnt/β-catenin signalling plays essential roles in embryonic development as well as tissue
homoeostasis in adults. Thus abnormal regulation of Wnt/β-catenin signalling is linked to a …

Deubiquitinases (DUBs) play important roles and therefore are potential drug targets in
various diseases including cancer and neurodegeneration. In this review, we recapitulate …

Protein ubiquitylation and sumoylation play key roles in regulating cellular responses to
DNA double-strand breaks (DSBs). Here, we show that human RNF4, a small ubiquitin-like …

Chromosome instability (CIN) is observed in most solid tumors and is linked to somatic
mutations in genome integrity maintenance genes. The spectrum of mutations that cause …

The regulation of Ubiquitin (Ub) conjugates generated by the complex network of proteins
that promote the mammalian DNA double‐strand break (DSB) response is not fully …

The proper functioning of the cell depends on preserving the cellular genome. In yeast cells,
a limited number of genes are located on mitochondrial DNA. Although the mechanisms …

During meiosis, paired homologous chromosomes (homologs) become linked via the
synaptonemal complex (SC) and crossovers. Crossovers mediate homolog segregation and …

Genome integrity is jeopardized each time DNA replication forks stall or collapse. Here we
report the identification of a complex composed of MMS22L (C6ORF167) and TONSL …

Replication stress involving collision of replisomes with camptothecin (CPT)-stabilized DNA-
Topoisomerase I adducts activates an ATR-dependent pathway to promote repair by …

To protect the genome, cells have evolved a diverse set of pathways designed to sense,
signal, and repair multiple types of DNA damage. To assess the degree of coordination and …