The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

High O2 consumption, modest antioxidant defenses and a lipid‐rich constitution make the
brain highly vulnerable to redox imbalances. Oxidative damage in the brain causes nervous …

Diabetes is one of the most frequent diseases throughout the world and its incidence is
predicted to exponentially progress in the future. This metabolic disorder is associated with …

Alzheimer's disease is the most common and lethal neurodegenerative disorder. The major
hallmarks of Alzheimer's disease are extracellular aggregation of amyloid β peptides and …

Aims Rupture-prone atherosclerotic plaques are characterized by inflammation and a large
necrotic core. Inflammation is linked to high metabolic activity. Advanced glycation …

Methylglyoxal (MGO), an active metabolite of glucose, is observed in high levels in the
tissues and blood of diabetic patients. Phosphocreatine (PCr), a high-energy phosphate …

Methylglyoxal is an α-oxoaldehyde inevitably produced from triose-phosphate intermediates
of phosphorylating glycolysis, and also from amino acids and acetone. Recently, the …

Aging is a multifactorial process that involves changes at the cellular, tissue, organ and the
whole body levels resulting in decreased functioning, development of diseases, and …

Methylglyoxal (MG) is a highly reactive compound derived mainly from glucose and fructose
metabolism. This metabolite has been implicated in diabetic complications as it is a strong …

The development of a competent oocyte intimately depends on the maintenance of
energetic homeostasis in the ovarian and follicular microenvironment. On this basis, it is very …