Fatty acid metabolism in the progression and resolution of CNS disorders
Recent advances in lipidomics and metabolomics have unveiled the complexity of fatty acid
metabolism and the fatty acid lipidome in health and disease. A growing body of evidence …
metabolism and the fatty acid lipidome in health and disease. A growing body of evidence …
[HTML][HTML] Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection
NG Bazan - Molecular aspects of medicine, 2018 - Elsevier
The functional significance of the selective enrichment of the omega-3 essential fatty acid
docosahexaenoic acid (DHA; 22C and 6 double bonds) in cellular membrane phospholipids …
docosahexaenoic acid (DHA; 22C and 6 double bonds) in cellular membrane phospholipids …
Novel cellular functions of very long chain-fatty acids: insight from ELOVL4 mutations
F Deák, RE Anderson, JL Fessler… - Frontiers in cellular …, 2019 - frontiersin.org
Elongation of Very Long chain fatty acids-4 (ELOVL4) protein is a member of the ELOVL
family of fatty acid elongases that is collectively responsible for catalyzing formation of long …
family of fatty acid elongases that is collectively responsible for catalyzing formation of long …
Nomenclature of genetic movement disorders: recommendations of the International Parkinson and Movement Disorder Society task force–an update
LM Lange, P Gonzalez‐Latapi… - Movement …, 2022 - Wiley Online Library
Abstract In 2016, the Movement Disorder Society Task Force for the Nomenclature of
Genetic Movement Disorders presented a new system for naming genetically determined …
Genetic Movement Disorders presented a new system for naming genetically determined …
Very long chain fatty acid-containing lipids: a decade of novel insights from the study of ELOVL4
GK Yeboah, ES Lobanova, RS Brush… - Journal of Lipid Research, 2021 - ASBMB
Lipids play essential roles in maintaining cell structure and function by modulating
membrane fluidity and cell signaling. The fatty acid elongase-4 (ELOVL4) protein, expressed …
membrane fluidity and cell signaling. The fatty acid elongase-4 (ELOVL4) protein, expressed …
[HTML][HTML] Targeted exome analysis identifies the genetic basis of disease in over 50% of patients with a wide range of ataxia-related phenotypes
M Sun, AK Johnson, V Nelakuditi, L Guidugli… - Genetics in …, 2019 - Elsevier
Purpose To examine the impact of a targeted exome approach for the molecular diagnosis
of patients nationwide with a wide range of ataxia-related phenotypes. Methods One …
of patients nationwide with a wide range of ataxia-related phenotypes. Methods One …
Elovanoids are novel cell-specific lipid mediators necessary for neuroprotective signaling for photoreceptor cell integrity
B Jun, PK Mukherjee, A Asatryan, MA Kautzmann… - Scientific reports, 2017 - nature.com
Abstract Docosahexaenoic acid (DHA, 22: 6 n-3) is abundant in the retina and is
enzymatically converted into pro-homeostatic docosanoids. The DHA-or eicosapentaenoic …
enzymatically converted into pro-homeostatic docosanoids. The DHA-or eicosapentaenoic …
De novo mutation in ELOVL1 causes ichthyosis, acanthosis nigricans, hypomyelination, spastic paraplegia, high frequency deafness and optic atrophy
N Mueller, T Sassa, S Morales-Gonzalez… - Journal of medical …, 2019 - jmg.bmj.com
Background Very long-chain fatty acids (VLCFAs) are essential for functioning of biological
membranes. ELOVL fatty acid elongase 1 catalyses elongation of saturated and …
membranes. ELOVL fatty acid elongase 1 catalyses elongation of saturated and …
[HTML][HTML] ELOVL4: Very long-chain fatty acids serve an eclectic role in mammalian health and function
BR Hopiavuori, RE Anderson, MP Agbaga - Progress in retinal and eye …, 2019 - Elsevier
Abstract ELOngation of Very Long chain fatty acids-4 (ELOVL4) is an elongase responsible
for the biosynthesis of very long chain (VLC,≥ C28) saturated (VLC-SFA) and …
for the biosynthesis of very long chain (VLC,≥ C28) saturated (VLC-SFA) and …
ELOVL4 mutations that cause spinocerebellar ataxia-34 differentially alter very long chain fatty acid biosynthesis
YK Gyening, NK Chauhan, M Tytanic, V Ea… - Journal of Lipid …, 2023 - ASBMB
Abstract The FA Elongase-4 (ELOVL4) enzyme mediates biosynthesis of both very long
chain (VLC)-PUFAs and VLC-saturated FA (VLC-SFAs). VLC-PUFAs play critical roles in …
chain (VLC)-PUFAs and VLC-saturated FA (VLC-SFAs). VLC-PUFAs play critical roles in …