Emerging evidence indicates that metabolism not only is a source of energy and
biomaterials for cell division but also acts as a driver of cancer cell plasticity and treatment …

Abstract N 6-methyladenosine (m 6 A) is the most prevalent internal mRNA modification.
Recent research has highlighted its role as a key regulator of gene expression, influencing …

Dear Editor, N6-methyladenosine (m6A) is a critical mRNA modification catalyzed by the
enzyme methyltransferase-like 3 (METTL3), with implications in RNA metabolism. METTL3 …

Methylation of adenine N6 (m6A) is the most frequent RNA modification. On mRNA, it is
catalyzed by the METTL3–14 heterodimer complex, which plays a key role in acute myeloid …

Highlights•The epitrascriptome and its modulators are attractive therapeutic targets.•Different
strategies to target the epitranscriptome are under investigation.•Small molecule inhibitors of …

Chemical modifications of ribonucleotides significantly alter the physicochemical properties
and functions of RNA. Initially perceived as static and essential marks in ribosomal RNA …

Cancer stem cells (CSCs) are a small population of less differentiated cells with robust self-
renewal ability. CSCs have been recognized as the root cause of tumor initiation …

Triple-negative breast cancer (TNBC) is one of the most difficult subtypes of breast cancer to
treat due to its distinct clinical and molecular characteristics. Patients with TNBC face a high …

Hematopoietic development is tightly regulated by various factors. The role of RNA m6A
modification during fetal hematopoiesis, particularly in megakaryopoiesis, remains unclear …

Single-cell technologies offer a unique opportunity to explore cellular heterogeneity in
hematopoiesis, reveal malignant hematopoietic cells with clinically significant features and …