Toxicities following CAR-T therapy for hematological malignancies

R Hernani, A Benzaquén, C Solano - Cancer Treatment Reviews, 2022 - Elsevier
Chimeric antigen receptor T-cell (CAR-T) therapy has improved outcomes in patients with
relapsed/refractory hematological malignancies. Research is also extending to other …

Risk of infection in patients with hematological malignancies receiving CAR T-cell therapy: systematic review and meta-analysis

G Telli Dizman, JM Aguado… - Expert review of anti …, 2022 - Taylor & Francis
Background Chimeric antigen receptor (CAR) T-cell therapy has emerged as a promising
treatment option for relapsed or refractory B-cell malignancies and multiple myeloma …

[HTML][HTML] Infections in haematology patients treated with CAR-T therapies: A systematic review and meta-analysis

GK Reynolds, B Sim, T Spelman, A Thomas… - Critical Reviews in …, 2023 - Elsevier
Abstract A registered (PROSPERO-CRD42022346462) systematic review and meta-
analysis was conducted of all-grade infections amongst adult patients receiving CAR-T …

Effects of B-cell lymphoma on the immune system and immune recovery after treatment: the paradigm of targeted therapy

S Mancuso, M Mattana, M Carlisi, M Santoro… - International Journal of …, 2022 - mdpi.com
B-cell lymphoma and lymphoproliferative diseases represent a heterogeneous and complex
group of neoplasms that are accompanied by a broad range of immune regulatory disorder …

Understanding the Etiology of Pancytopenias in the CAR T-Cell Therapy Setting: What We Know and What We Don't?

F Yassine, H Murthy, E Ghabashi… - … /Oncology and Stem …, 2022 - journals.lww.com
Chimeric antigen receptor T-cell (CAR T-cell) therapy represents an innovative and
transformative therapy for patients with relapsed and/or refractory (R/R) hematological …

How I treat refractory/relapsed diffuse large B‐cell lymphomas with CD19‐directed chimeric antigen receptor T cells

A Nagler, VM Perriello, L Falini… - British Journal of …, 2023 - Wiley Online Library
Chimeric antigen receptor (CAR) T cells targeting CD19 represent a promising salvage
immunotherapy for relapsed/refractory diffuse large B‐cell lymphoma (R/R DLBCL) …

[HTML][HTML] Predicting infections in patients with haematological malignancies treated with chimeric antigen receptor T-cell therapies: A systematic scoping review and …

G Reynolds, B Sim, MA Anderson, T Spelman… - Clinical Microbiology …, 2023 - Elsevier
Background Chimeric antigen receptor T cells (CAR-T cells) are increasingly used to treat
haematological malignancies. Strategies for preventing infections in CAR-T-treated patients …

Inflammatory abrasion of hematopoietic stem cells: a candidate clue for the post-CAR-T hematotoxicity?

T Sun, D Li, L Huang, X Zhu - Frontiers in Immunology, 2023 - frontiersin.org
Chimeric antigen receptor T-cell (CAR-T) therapy has shown remarkable effects in treating
various hematological malignancies. However, hematotoxicity, specifically neutropenia …

Chimeric antigen receptor-T-cell therapies going viral: latent and incidental viral infections

E Kampouri, G Reynolds, BW Teh… - Current Opinion in …, 2024 - journals.lww.com
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Early and Late Toxicities of Chimeric Antigen Receptor T-Cells

R Epperly, VM Giordani… - Hematology …, 2023 - hemonc.theclinics.com
Managing inflammatory toxicities related to chimeric antigen receptor (CAR) T-cells is an
essential component to facilitate its use as an important therapeutic and allow for its …