Diabetes, a silent killer, is one of the most widely prevalent conditions of the present time.
According to the 2017 International Diabetes Federation (IDF) statistics, the global …

Adipose tissue is a complex dynamic organ with whole-body immunometabolic influence.
Much of the work into understanding the role of immune cells in adipose tissue has been in …

Short-chain fatty acids (SCFAs) are the main products of dietary fiber fermentation and are
believed to drive the fiber-related prevention of the metabolic syndrome. Here we show that …

Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear receptor
(NR) superfamily of ligand-dependent transcription factors (TFs) and function as a master …

Whereas in most cases a fatty liver remains free of inflammation, 10%‐20% of patients who
have fatty liver develop inflammation and fibrosis (nonalcoholic steatohepatitis [NASH]) …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Hyperinsulinemia is associated with obesity and pancreatic islet hyperplasia, but whether
insulin causes these phenomena or is a compensatory response has remained unsettled for …

Diabetes mellitus type 2 (T2DM) is a metabolic disorder develops due to the overproduction
of free radicals where oxidative stress could contribute it. Possible factors are defective …

Metabolic homeostasis in the organism is assured both by the nervous system and by
hormones. Among a plethora of hormones regulating metabolism, serotonin presents a …

The obesity epidemic has focused attention on adipose tissue and the development of fat
cells (ie adipocytes), which is known as adipogenesis. Peroxisome proliferator-activated …