Abstract Background Cancer-induced Bone Pain (CIBP) is an important factor affecting their
quality of life of cancer survivors. In addition, current clinical practice and scientific research …

Pain plays an indispensable role as an alarm system to protect us from dangers or injuries.
However, neuropathic pain, a debilitating pain condition caused by damage to the nervous …

In neuropathic pain, recent evidence has highlighted a sex-dependent role of the P2X4
receptor in spinal microglia in the development of tactile allodynia following nerve injury …

Chronic pain is a common symptom of most clinical diseases, which seriously affects the
psychosomatic health of patients and brings some pain to patients. Due to its pathological …

Abstract The P2X4 receptor (P2X4) is an ATP-gated cation channel that is highly permeable
to Ca 2+ and widely expressed in neuronal and glial cell types throughout the central …

Neuropathic pain (NPP) is a common symptom of most diseases in clinic, which seriously
affects the mental health of patients and brings certain pain to patients. Due to its …

Animal models of pain consist of modeling a pain-like state and measuring the consequent
behavior. The first animal models of neuropathic pain (NP) were developed in rodents with a …

Objective Intense inflammation may result in pain, which manifests as spinal central
sensitization. There is growing evidence that purinergic signaling plays a pivotal role in the …

Many factors are involved in the development of cancer pain, which is a serious
complication of cancer and affects the quality of life of patients, Normally, drugs are used to …

In response to changes in activity induced by environmental cues, neurons in the central
nervous system undergo homeostatic plasticity to sustain overall network function during …