Recent research has demonstrated that the non-coding genome plays a key role in genetic
programming and gene regulation during development as well as in health and …

A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

Rationale for Study: MicroRNAs (miRNAs) are small noncoding RNAs that regulate protein
expression at post-transcriptional level. We hypothesized that a specific pool of endothelial …

Noncoding RNAs have been shown to exert important physiological and pathophysiological
functions. Various studies suggest that modulating noncoding RNAs may provide a …

Atherosclerosis is a complex multifactorial disease that, despite advances in lifestyle
management and drug therapy, remains to be the major cause of high morbidity and …

Background The treatment of muscle wasting is accompanied by benefits in other organs,
possibly resulting from muscle–organ crosstalk. However, how the muscle communicates …

Rationale: Blood flow–induced shear stress controls endothelial cell (EC) physiology during
atherosclerosis via transcriptional mechanisms that are incompletely understood. The …

Abstract The microRNA family, miR-181, plays diverse roles in regulating key aspects of
cellular growth, development, and activation. Accumulating evidence supports a central role …

Epidemiological studies in large cohorts support the notion that physical fitness is
associated with reduced cardiovascular mortality and hospitalization due to cardiovascular …

We investigated the role of micro RNA s (mi RNA) in endothelial dysfunction in the setting of
cardiometabolic disorders represented by type 2 diabetes mellitus (T2DM). miR‐29 was …