[HTML][HTML] Recent progress in Lyme disease and remaining challenges

JR Bobe, BL Jutras, EJ Horn, ME Embers… - Frontiers in …, 2021 - frontiersin.org
Lyme disease (also known as Lyme borreliosis) is the most common vector-borne disease in
the United States with an estimated 476,000 cases per year. While historically, the long-term …

[PDF][PDF] Persistent symptoms after treatment of Lyme disease

A Marques - Infectious disease clinics of North America, 2022 - Elsevier
The controversy regarding the underlying mechanisms of PTLDs and the increasingly bitter
debate over CLD, continues unabated over the past years. If anything, it has become more …

[HTML][HTML] A selective antibiotic for Lyme disease

N Leimer, X Wu, Y Imai, M Morrissette, N Pitt… - Cell, 2021 - cell.com
Lyme disease is on the rise. Caused by a spirochete Borreliella burgdorferi, it affects an
estimated 500,000 people in the United States alone. The antibiotics currently used to treat …

Lyme borreliosis and associations with mental disorders and suicidal behavior: a nationwide Danish cohort study

BA Fallon, T Madsen, A Erlangsen… - American journal of …, 2021 - Am Psychiatric Assoc
Objective: Lyme borreliosis is a tick-borne infectious disease that may confer an increased
risk of mental disorders, but previous studies have been hampered by methodological …

[HTML][HTML] Lyme disease and the pursuit of a clinical cure

H Adkison, ME Embers - Frontiers in Medicine, 2023 - frontiersin.org
Lyme disease, caused by the spirochete Borrelia burgdorferi, is the most common vector-
borne illness in the United States. Many aspects of the disease are still topics of controversy …

[HTML][HTML] The microbiome in post-acute infection syndrome (PAIS)

C Guo, B Yi, J Wu, J Lu - Computational and Structural Biotechnology …, 2023 - Elsevier
ABSTRACT Post-Acute Infection Syndrome (PAIS) is a relatively new medical terminology
that represents prolonged sequelae symptoms after acute infection by numerous pathogenic …

[HTML][HTML] Neuropathogenicity of non-viable Borrelia burgdorferi ex vivo

G Parthasarathy, SKG Gadila - Scientific Reports, 2022 - nature.com
Even after appropriate treatment, a proportion of Lyme disease patients suffer from a
constellation of symptoms, collectively called Post-Treatment Lyme Disease Syndrome …

[HTML][HTML] Lyme Neuroborreliosis: Mechanisms of B. burgdorferi Infection of the Nervous System

L Ford, DM Tufts - Brain sciences, 2021 - mdpi.com
Lyme borreliosis is the most prevalent tick-borne disease in the United States, infecting~
476,000 people annually. Borrelia spp. spirochetal bacteria are the causative agents of …

[HTML][HTML] Lyme Disease and Post-treatment Lyme Disease Syndrome: current and developing treatment options

NC Talbot, NJ Spillers, P Luther, C Flanagan… - Cureus, 2023 - ncbi.nlm.nih.gov
Lyme disease and its treatment implications have become an ever-increasing area of
concern within the United States related to the markedly increased prevalence of infection …

[HTML][HTML] Neurological pain, psychological symptoms, and diagnostic struggles among patients with tick-borne diseases

SP Maxwell, C Brooks, CL McNeely, KC Thomas - Healthcare, 2022 - mdpi.com
Public health reports contain limited information regarding the psychological and
neurological symptoms of tick-borne diseases (TBDs). Employing a mixed-method …