Disordered proteins and nucleic acids play key roles in cellular function and disease. Here,
we review recent advances in the computational exploration of the conformational dynamics …

The paradigmatic disordered protein tau plays an important role in neuronal function and
neurodegenerative diseases. To disentangle the factors controlling the balance between …

The concept of intrinsically disordered proteins (IDPs) has emerged relatively slowly, but
over the past 20 years, it has become an intense research area in structural biology. Indeed …

Huntington's disease is a neurodegenerative disorder caused by a CAG expansion in the
first exon of the HTT gene, resulting in an extended polyglutamine (poly-Q) tract in huntingtin …

Many disordered proteins conserve essential functions in the face of extensive sequence
variation, making it challenging to identify the mechanisms responsible for functional …

The power of structural information for informing biological mechanisms is clear for stable
folded macromolecules, but similar structure–function insight is more difficult to obtain for …

The causative agent of Huntington's disease, the poly-Q homo-repeat in the N-terminal
region of huntingtin (httex1), is flanked by a 17-residue-long fragment (N17) and a proline …

Intrinsically disordered proteins (IDPs) constitute a large fraction of the human proteome and
are critical in the regulation of cellular processes. A detailed understanding of the …

Intrinsically disordered proteins and flexible regions in multidomain proteins display
substantial conformational heterogeneity. Characterizing the conformational ensembles of …

Huntington's disease neurodegeneration occurs when the number of consecutive
glutamines in the huntingtin exon-1 (HTTExon1) exceeds a pathological threshold of 35. The …