Parenteral nutrition in clinical practice: international challenges and strategies

PE Wischmeyer, S Klek, MM Berger… - American Journal of …, 2024 - academic.oup.com
Purpose Parenteral nutrition (PN) is an established therapy when oral/enteral feeding is not
sufficient or is contraindicated, but nevertheless PN remains a complex, high-alert …

Impact of preformulation on drug development

SS Bharate, RA Vishwakarma - Expert opinion on drug delivery, 2013 - Taylor & Francis
Introduction: Preformulation assists scientists in screening lead candidates based on their
physicochemical and biopharmaceutical properties. This data is useful for selection of new …

Evaluation of the Stability of Newborn Hospital Parenteral Nutrition Solutions

L Otero-Millán, B Bea-Mascato, JL Legido Soto… - Pharmaceutics, 2024 - mdpi.com
(1) Background: parenteral nutrition (PN) solutions are an extremely complex mixture. It is
composed of a multitude of chemical elements that can give rise to a large number of …

Co-administration of Intravenous Drugs: Rapidly Troubleshooting the Solid Form Composition of a Precipitate in a Multi-drug Mixture Using On-Site Raman …

N Nilsson, K Nezvalova-Henriksen… - Molecular …, 2023 - ACS Publications
Intravenous drugs are often co-administrated in the same intravenous catheter line due to
which compatibility issues, such as complex precipitation processes in the catheter line, may …

Hypophosphatemia is prevalent among preterm infants less than 1,500 grams

H Al-Wassia, AW Lyon, SM Rose… - American Journal of …, 2019 - thieme-connect.com
Objective This article identifies the prevalence and associated factors of hypophosphatemia
(HP) in very low birth weight (VLBW) infants in the first week of life. Study Design …

Calcium chloride and sodium phosphate in neonatal parenteral nutrition containing TrophAmine: precipitation studies and aluminum content

EA Migaki, BJ Melhart, CJ Dewar… - Journal of Parenteral …, 2012 - Wiley Online Library
Objectives: The objectives were to determine concentrations of calcium chloride (CaCl) and
sodium phosphate (NaPhos) that can be safely added to TrophAmine‐based parenteral …

Compatibility of maximum inorganic and organic calcium and phosphate content in neonatal parenteral solutions

D Watrobska-Swietlikowska - Scientific Reports, 2019 - nature.com
The purpose of the study was to determine the maximum safe concentration of calcium and
phosphate in neonatal parenteral nutrition (PN) solutions when various combinations of …

Y-Site Compatibility Studies of Parenteral Nutrition and Other Intravenous Medications in Neonatal and Pediatric Patients: A Review of the Literature Evidence

A Gostyńska, T Przybylski, M Ogrodowczyk - Pharmaceutics, 2024 - mdpi.com
Background: Polytherapy in neonatal and pediatric patients requiring parenteral nutrition
(PN) administration is a challenging task. Due to limited intravenous access, the Y-site …

Aluminum content of neonatal parenteral nutrition solutions: Options for reducing aluminum exposure

RK Huston, CF Heisel, BR Vermillion… - Nutrition in Clinical …, 2017 - Wiley Online Library
Introduction: Calcium chloride (CaCl2) has been the only calcium additive available in the
United States that has a low aluminum (Al) content. Calcium gluconate in glass vials …

Electron Microscopy for the Stability Assessment of Parenteral Nutrition Admixtures: Focus on Precipitation

L Otero-Millán, B Bea-Mascato, JL Legido Soto… - Nutrients, 2024 - mdpi.com
(1) Background: parenteral nutrition (PN) is indispensable for patients unable to receive oral
or enteral feeding. However, the complexity of PN solutions presents challenges regarding …