Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a conserved
protein kinase that plays essential roles in various biological processes. It is located in the …

The increasing population will challenge healthcare, particularly because the worldwide
population has never been older. Therapeutic solutions to age-related disease will be …

Neurodegenerative diseases such as Alzheimer's disease (AD) are multifactorial with
several different pathologic mechanisms. Therefore, it is assumed that multitargeted-directed …

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is an evolutionarily
conserved protein kinase and the most studied member of the Dual-specificity tyrosine …

Overexpression of the chromosome 21 DYRK1A gene induces morphological defects and
cognitive impairments in individuals with Down syndrome (DS) and in DS mice models …

In neurodegenerative diseases, using a single molecule that can exert multiple effects to
modify the disease may have superior activity over the classical “one molecule-one target” …

α-Synuclein (α-Syn) aggregates are implicated in Parkinson's disease (PD), so inhibitors of
α-Syn aggregation have been intensively explored. It has been demonstrated that small …

Diabetes Mellitus (DM) is a chronic metabolic disorder characterized by β-cell loss and
inflammation. From a therapeutic standpoint, it would be necessary to halt the uncontrolled …

In this study, three series of polydentate N, O-ligands possessing unsymmetrical urea
fragments attached to ap-cresol scaffold are obtained, namely mono-and bi-substituted open …

Dementia with Lewy Bodies is a neurodegenerative disorder characterised by abnormal α-
synuclein aggregate accumulation in Lewy Bodies and Lewy Neurites and the most …