[HTML][HTML] Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis

J Wang, K Hu, X Cai, B Yang, Q He, J Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic interstitial pneumonia
with unknown causes. The incidence rate increases year by year and the prognosis is poor …

Idiopathic pulmonary fibrosis

L Richeldi, HR Collard, MG Jones - The Lancet, 2017 - thelancet.com
Idiopathic pulmonary fibrosis is a prototype of chronic, progressive, and fibrotic lung disease.
Healthy tissue is replaced by altered extracellular matrix and alveolar architecture is …

[HTML][HTML] SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory tract

YJ Hou, K Okuda, CE Edwards, DR Martinez… - Cell, 2020 - cell.com
The mode of acquisition and causes for the variable clinical spectrum of coronavirus disease
2019 (COVID-19) remain unknown. We utilized a reverse genetics system to generate a …

Idiopathic pulmonary fibrosis: pathogenesis and management

G Sgalla, B Iovene, M Calvello, M Ori, F Varone… - Respiratory …, 2018 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease
characterized by the aberrant accumulation of fibrotic tissue in the lungs parenchyma …

[HTML][HTML] From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic?

JE Michalski, JS Kurche, DA Schwartz - Translational Research, 2022 - Elsevier
While the coronavirus disease 19 (COVID-19) pandemic has transformed the medical and
scientific communites since it was first reported in late 2019, we are only beginning to …

Macrophages: friend or foe in idiopathic pulmonary fibrosis?

L Zhang, Y Wang, G Wu, W Xiong, W Gu, CY Wang - Respiratory research, 2018 - Springer
Idiopathic pulmonary fibrosis (IPF) is a prototype of lethal, chronic, progressive interstitial
lung disease of unknown etiology. Over the past decade, macrophage has been recognized …

Mucins, mucus, and goblet cells

J Ma, BK Rubin, JA Voynow - Chest, 2018 - Elsevier
The respiratory epithelium is lined by mucus, a gel consisting of water, ions, proteins, and
macromolecules. The major macromolecular components of mucus are the mucin …

Idiopathic pulmonary fibrosis (IPF): an overview

SL Barratt, A Creamer, C Hayton… - Journal of clinical …, 2018 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterised by chronic,
progressive scarring of the lungs and the pathological hallmark of usual interstitial …

Chronic respiratory diseases: a global view

WW Labaki, MLK Han - The Lancet Respiratory Medicine, 2020 - thelancet.com
Chronic respiratory diseases are among the most common non-communicable diseases
worldwide, largely due to the ubiquity of noxious environmental, occupational, and …

Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease

E Valenzi, M Bulik, T Tabib, C Morse… - Annals of the …, 2019 - ard.bmj.com
Objectives Myofibroblasts are key effector cells in the extracellular matrix remodelling of
systemic sclerosis-associated interstitial lung disease (SSc-ILD); however, the diversity of …