IFN-I mediates lupus nephritis from the beginning to renal fibrosis

X Ding, Y Ren, X He - Frontiers in immunology, 2021 - frontiersin.org
Lupus nephritis (LN) is a common complication of systemic lupus erythematosus (SLE) and
a major risk factor for morbidity and mortality. The abundant cell-free nucleic (DNA/RNA) in …

PD-1 immunobiology in systemic lupus erythematosus

CS Curran, S Gupta, I Sanz, E Sharon - Journal of autoimmunity, 2019 - Elsevier
Abstract Programmed death (PD)-1 receptors and their ligands have been identified in the
pathogenesis and development of systemic lupus erythematosus (SLE). Two key pathways …

Serum of post-COVID-19 syndrome patients with or without ME/CFS differentially affects endothelial cell function in vitro

L Flaskamp, C Roubal, S Uddin, F Sotzny, C Kedor… - Cells, 2022 - mdpi.com
A proportion of COVID-19 reconvalescent patients develop post-COVID-19 syndrome (PCS)
including a subgroup fulfilling diagnostic criteria of Myalgic encephalomyelitis/Chronic …

Anti-dsDNA antibodies increase the cardiovascular risk in systemic lupus erythematosus promoting a distinctive immune and vascular activation

AM Patiño-Trives, C Pérez-Sánchez… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Systemic lupus erythematosus (SLE) is associated to boosted atherosclerosis
development and a higher cardiovascular disease risk. This study aimed to delineate the …

Sphingosine 1‐Phosphate Receptor 1 Signaling Maintains Endothelial Cell Barrier Function and Protects Against Immune Complex–Induced Vascular Injury

N Burg, S Swendeman, S Worgall, T Hla… - Arthritis & …, 2018 - Wiley Online Library
Objective Immune complex (IC) deposition activates polymorphonuclear neutrophils (PMN
s), increases vascular permeability, and leads to organ damage in systemic lupus …

Pentraxin 3: A promising therapeutic target for autoimmune diseases

Q Wu, F Cao, J Tao, X Li, SG Zheng, HF Pan - Autoimmunity Reviews, 2020 - Elsevier
Abstract Pentraxin 3 (PTX3) is a prototypic humoral soluble pattern recognition molecule that
exerts a pivotal role in innate immune response and inflammation, as well as in tissue …

Protective effects of hydroxychloroquine against accelerated atherosclerosis in systemic lupus erythematosus

A Floris, M Piga, AA Mangoni… - Mediators of …, 2018 - Wiley Online Library
Cardiovascular (CV) morbidity and mortality are a challenge in management of patients with
systemic lupus erythematosus (SLE). Higher risk of CV disease in SLE patients is mostly …

Complement mediated endothelial damage in thrombotic microangiopathies

M Blasco, E Guillén-Olmos, M Diaz-Ricart… - Frontiers in …, 2022 - frontiersin.org
Thrombotic microangiopathies (TMA) constitute a group of different disorders that have a
common underlying mechanism: the endothelial damage. These disorders may exhibit …

Renal microvascular lesions in lupus nephritis

Y Ding, Y Tan, Z Qu, F Yu - Renal failure, 2020 - Taylor & Francis
Renal microvascular lesions, common in lupus nephritis (LN), are associated with long-term
poor outcomes. There are mainly five pathological types of renal microvascular lesions in …

Neuropsychiatric systemic lupus erythematosus: molecules involved in its imunopathogenesis, clinical features, and treatment

AA Justiz-Vaillant, D Gopaul, S Soodeen… - Molecules, 2024 - mdpi.com
Systemic lupus erythematosus (SLE) is an idiopathic chronic autoimmune disease that can
affect any organ in the body, including the neurological system. Multiple factors, such as …