Continuous manufacturing of active pharmaceutical ingredients: current trends and perspectives

A Hyer, D Gregory, K Kay, Q Le… - Advanced Synthesis …, 2024 - Wiley Online Library
The pharmaceutical industry has traditionally employed batch processing as a means of
synthesizing active pharmaceutical ingredients (APIs) on a commercial scale. Batch …

Process of ammonia removal from anaerobic digestion and associated ammonium sulphate production: Pilot plant demonstration

P Costamagna, A Giordano, Y Lazzarini… - Journal of environmental …, 2020 - Elsevier
A process for the continuous extraction of ammonia from anaerobic digesters is proposed. In
this process, a portion of the sludge treated in the digesters is continuously withdrawn and …

System for ammonia removal from anaerobic digestion and associated ammonium sulfate production: Simulation and design considerations

P Costamagna, M Delucchi, G Busca… - Process Safety and …, 2020 - Elsevier
A side-stream ammonia stripping system coupled with a full-scale anaerobic digestion plant
is considered. The system is based on an ammonia stripping unit (thin film evaporator, TFE) …

Thin-film evaporator model for continuous active pharmaceutical ingredient manufacturing

BW Lee, K Yin, K Splaine, B Roesch - Industrial & Engineering …, 2020 - ACS Publications
Thin-film evaporator (TFE) is a popular continuous distillation/evaporation technology for
pharmaceutical and fine chemical industries and has several equipment and process …

[PDF][PDF] Indirect series of falling film distillation column to process synthetic naphtha

MV Querino, C Marangoni, RAF Machado - Chem. Eng. Trans., 2018 - folk.ntnu.no
The separation of multicomponent mixture by distillation is commonly accomplished by
means of a sequence of columns and/or lateral withdrawals on a column. Desirable …

A new approach to simulate the fluid dynamics in a wiped film evaporator using Modelica

D Appelhaus, K Jasch, S Jahnke, HHK Bin… - … Research and Design, 2020 - Elsevier
Wiped film evaporators (WFE) or agitated thin film evaporators are efficient equipment for
separating highly thermosensitive and viscous mixtures. There are different approaches to …

[PDF][PDF] A simulation of evaporation dissolution process for a lyocell solution in a vertical wiped film evaporator (1: Simulation of flow process for solution)

CJ Ri, YC Kim, SW Kim, JH Chloe - Cellul. Chem. Technol, 2023 - cellulosechemtechnol.ro
Vertical wiped film evaporators (VWFE) have found wide application in chemical, food and
especially, fiber industries. In this paper, a mathematical simulation is represented for the …

Electronic Structure and Optical Properties of Oxygen Vacancy and Ag-Doped SnO2 Sensors

Y Li, YX Zhang, X Zhang, YP Ding, JY Tang… - Chemical Engineering …, 2016 - cetjournal.it
Crystal structure, electronic and optical performance of oxygen vacancies defects and Ag-
doped were calculated for SnO 2 (rutile) semiconductor. In this paper, the examines were …

Process Intensification via Batch-To-Continuous Transition in The Production of Specialty Chemicals

N Al Azri - 2022 - search.proquest.com
Production of specialty chemicals to-date is conducted in simple, but inefficient large-volume
batch reactors. However, this industry is facing challenges due to supply chain limitations …

Automatic control system of the evaporator in the technology of spent nuclear fuel processing

AV Vilnina, E Efremov, AO Pletnev, Y Chursin… - Chemical Engineering …, 2017 - cetjournal.it
The operation of the radiochemical plant is impossible without high-quality automatic control
systems. In the technologies of spent nuclear fuel reprocessing, the method of continuous …