T cell receptor (TCR) signaling in health and disease

K Shah, A Al-Haidari, J Sun, JU Kazi - Signal transduction and targeted …, 2021 - nature.com
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …

Mechanisms of type-I-and type-II-interferon-mediated signalling

LC Platanias - Nature Reviews Immunology, 2005 - nature.com
Interferons are cytokines that have antiviral, antiproliferative and immunomodulatory effects.
Because of these important properties, in the past two decades, major research efforts have …

MicroRNAs—the micro steering wheel of tumour metastases

MS Nicoloso, R Spizzo, M Shimizu, S Rossi… - Nature Reviews …, 2009 - nature.com
Recently, microRNAs (miRNAs) have been discovered to have a role in metastasis. Here we
describe how miRNAs are involved in advanced stages of tumour progression, stressing …

Genetic insights into the mechanisms of Fgf signaling

JR Brewer, P Mazot, P Soriano - Genes & development, 2016 - genesdev.cshlp.org
The fibroblast growth factor (Fgf) family of ligands and receptor tyrosine kinases is required
throughout embryonic and postnatal development and also regulates multiple homeostatic …

Fluorescent proteins as genetically encoded FRET biosensors in life sciences

B Hochreiter, A Pardo Garcia, JA Schmid - Sensors, 2015 - mdpi.com
Fluorescence-or Förster resonance energy transfer (FRET) is a measurable physical energy
transfer phenomenon between appropriate chromophores, when they are in sufficient …

Role of integrins in endothelial mechanosensing of shear stress

JYJ Shyy, S Chien - Circulation research, 2002 - Am Heart Assoc
The focal pattern of atherosclerotic lesions in arterial vessels suggests that local blood flow
patterns are important factors in atherosclerosis. Although disturbed flows in the branches …

Apoptotic cell recognition receptors and scavenger receptors

KK Penberthy, KS Ravichandran - Immunological reviews, 2016 - Wiley Online Library
Phosphatidylserine recognition receptors are a highly diverse set of receptors grouped by
their ability to recognize the 'eat‐me'signal phosphatidylserine on apoptotic cells. Most of the …

Signal transduction via the stem cell factor receptor/c-Kit

L Rönnstrand - Cellular and Molecular Life Sciences CMLS, 2004 - Springer
Together with its ligand, stem cell factor, the receptor tyrosine kinase c-Kit is a key controlling
receptor for a number of cell types, including hematopoietic stem cells, mast cells …

The interplay between Src and integrins in normal and tumor biology

MP Playford, MD Schaller - Oncogene, 2004 - nature.com
Src family nonreceptor protein tyrosine kinases transduce signals that control normal cellular
processes such as cell proliferation, adhesion and motility. Normally, cellular Src is held in …

Regulation of skeletal muscle stem cells by fibroblast growth factors

B Pawlikowski, TO Vogler, K Gadek… - Developmental …, 2017 - Wiley Online Library
Fibroblast growth factors (FGFs) are essential for self‐renewal of skeletal muscle stem cells
(satellite cells) and required for maintenance and repair of skeletal muscle. Satellite cells …