CB2 receptor in the CNS: From immune and neuronal modulation to behavior
W Grabon, S Rheims, J Smith, J Bodennec… - Neuroscience & …, 2023 - Elsevier
Despite low levels of cannabinoid receptor type 2 (CB2R) expression in the central nervous
system in human and rodents, a growing body of evidence shows CB2R involvement in …
system in human and rodents, a growing body of evidence shows CB2R involvement in …
RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular …
U Grether, RH Foxton, S Gruener, C Korn… - Frontiers in …, 2024 - frontiersin.org
Introduction Preclinical studies suggest that cannabinoid receptor type 2 (CB2R) activation
has a therapeutic effect in animal models on chronic inflammation and vascular …
has a therapeutic effect in animal models on chronic inflammation and vascular …
[HTML][HTML] The Impact of the CB2 Cannabinoid Receptor in Inflammatory Diseases: An Update
The emergence of inflammatory diseases is a heavy burden on modern societies. Cannabis
has been used for several millennia to treat inflammatory disorders such as rheumatism or …
has been used for several millennia to treat inflammatory disorders such as rheumatism or …
A Highly Potent, Orally Bioavailable Pyrazole-Derived Cannabinoid CB2 Receptor- Selective Full Agonist for In Vivo Studies
The cannabinoid CB2 receptor (CB2R) is a potential therapeutic target for distinct forms of
tissue injury and inflammatory diseases. To thoroughly investigate the role of CB2R in …
tissue injury and inflammatory diseases. To thoroughly investigate the role of CB2R in …
Cannabinoid CB2 receptor orthologues; in vitro function and perspectives for preclinical to clinical translation
ER Carruthers, NL Grimsey - British Journal of Pharmacology, 2024 - Wiley Online Library
Cannabinoid CB2 receptor agonists are in development as therapeutic agents, including for
immune modulation and pain relief. Despite promising results in rodent preclinical studies …
immune modulation and pain relief. Despite promising results in rodent preclinical studies …
Mechanistic QSAR analysis to predict the binding affinity of diverse heterocycles as selective cannabinoid 2 receptor inhibitor
RD Jawarkar, MEA Zaki, SA Al-Hussain… - Journal of Taibah …, 2023 - Taylor & Francis
CB2R are fascinating targets for neuropathic pain and mood disorders because of their
improved biological characteristics. Experimental data on 1296 cannabinoid-2 receptor …
improved biological characteristics. Experimental data on 1296 cannabinoid-2 receptor …
[HTML][HTML] Is there a rational basis for cannabinoids research and development in ocular pain therapy? A systematic review of preclinical evidence
D Scuteri, L Rombolà, K Hamamura, T Sakurada… - Biomedicine & …, 2022 - Elsevier
Background Purpose of the present systematic review is to investigate preclinical evidence
in favor of the working hypothesis of efficacy of cannabinoids in ocular pain treatment …
in favor of the working hypothesis of efficacy of cannabinoids in ocular pain treatment …
Cannabinoid receptor type 2 ligands: an analysis of granted patents since 2010
The G-protein-coupled cannabinoid receptor type 2 (CB2R) is a key element of the
endocannabinoid (EC) system. EC/CB2R signaling has significant therapeutic potential in …
endocannabinoid (EC) system. EC/CB2R signaling has significant therapeutic potential in …
[引用][C] Goods and bads of the endocannabinoid system as a therapeutic target: Lessons learned after 30 years
[HTML][HTML] Cannabinoid-Based Ocular Therapies and Formulations
SM Saraiva, L Martín-Banderas, M Durán-Lobato - Pharmaceutics, 2023 - mdpi.com
The interest in the pharmacological applications of cannabinoids is largely increasing in a
wide range of medical areas. Recently, research on its potential role in eye conditions, many …
wide range of medical areas. Recently, research on its potential role in eye conditions, many …