Drug addiction, one of the major health problems worldwide, is characterized by the loss of
control in drug intake, craving, and withdrawal. At the individual level, drugs of abuse …

Background Substance use disorders (SUD) are a category of psychiatric disorders with a
large epidemiological and societal impact around the world. In the last decades, a large …

Substance use disorders are more prevalent in schizophrenia, but the causal links between
both conditions remain unclear. Maternal immune activation (MIA) is associated with …

Creatine (Cr) and phosphocreatine (PCr) are physiologically essential molecules for life,
given they serve as rapid and localized support of energy-and mechanical-dependent …

We previously identified a 210 kb region on chromosome 11 (50.37-50.58 Mb, mm10)
containing two protein-coding genes (Hnrnph1, Rufy1) that was necessary for reduced …

Schizophrenia (SZ) is a complex and severe psychiatric disorder, which has a global lifetime
prevalence of 0.4% and a heritability of around 0.81. A number of epigenome-wide …

Background and aims Genomic and transcriptomic findings greatly broaden the biological
knowledge regarding substance use. However, systematic convergence and comparison …

Motor disturbances strongly increase the burden of cocaine use disorder (CUDs). The
objective of our translational study was to identify the genes and biological pathways …

Astrocytes play pivotal roles in the brain and they become reactive under stress conditions.
Here, we carried out, for the first time, an integrative meta-analysis of genome-wide …

There is an overwhelming evidence proving that mental disorders are not the product of a
single risk factor–ie genetic variants or environmental factors, including exposure to …