Research progress on pleiotropic neuroprotective drugs for traumatic brain injury

Q Zhao, H Li, H Li, J Zhang - Frontiers in Pharmacology, 2023 - frontiersin.org
Traumatic brain injury (TBI) has become one of the most important causes of death and
disability worldwide. A series of neuroinflammatory responses induced after TBI are key …

[HTML][HTML] Treating traumatic brain injury with minocycline

PJ Bergold, R Furhang, S Lawless - Neurotherapeutics, 2023 - Elsevier
Traumatic brain injury (TBI) results in both rapid and delayed brain damage. The speed,
complexity, and persistence of TBI present large obstacles to drug development. Preclinical …

[HTML][HTML] Early posttraumatic CSF1R inhibition via PLX3397 leads to time-and sex-dependent effects on inflammation and neuronal maintenance after traumatic brain …

Y Wang, I Wernersbach, J Strehle, S Li, D Appel… - Brain, Behavior, and …, 2022 - Elsevier
Background There is a need for early therapeutic interventions after traumatic brain injury
(TBI) to prevent neurodegeneration. Microglia/macrophage (M/M) depletion and …

Pre-traumatic antibiotic-induced microbial depletion reduces neuroinflammation in acute murine traumatic brain injury

K Ritter, D Vetter, I Wernersbach, T Schwanz… - …, 2023 - Elsevier
The connection between dysbiosis of the gut microbiome and diseases and injuries of the
brain has attracted considerable interest in recent years. Interestingly, antibiotic-induced …

Nicotinamide mononucleotide prevents retinal dysfunction in a mouse model of retinal ischemia/reperfusion injury

D Lee, Y Tomita, Y Miwa, A Shinojima, N Ban… - International journal of …, 2022 - mdpi.com
Retinal ischemia/reperfusion (I/R) injury can cause severe vision impairment. Retinal I/R
injury is associated with pathological increases in reactive oxygen species and …

Traumatic brain injury and secondary neurodegenerative disease

WS Dodd, EJ Panther, K Pierre, JS Hernandez, D Patel… - Trauma Care, 2022 - mdpi.com
Traumatic brain injury (TBI) is a devastating event with severe long-term complications. TBI
and its sequelae are one of the leading causes of death and disability in those under 50 …

Deplete and repeat: microglial CSF1R inhibition and traumatic brain injury

R Boland, ON Kokiko-Cochran - Frontiers in Cellular Neuroscience, 2024 - frontiersin.org
Traumatic brain injury (TBI) is a public health burden affecting millions of people. Sustained
neuroinflammation after TBI is often associated with poor outcome. As a result, increased …

[HTML][HTML] P2X7R antagonism suppresses long-lasting brain hyperexcitability following traumatic brain injury in mice

M Alves, L de Diego-Garcia, G Vegliante… - …, 2025 - pmc.ncbi.nlm.nih.gov
Purpose: Post-traumatic epilepsy (PTE) is one of the most common life-quality reducing
consequences of traumatic brain injury (TBI). However, to date there are no pharmacological …

Structural preservation does not ensure function at sensory Ia–motoneuron synapses following peripheral nerve injury and repair

TM Rotterman, VV García, SN Housley… - Journal of …, 2023 - Soc Neuroscience
Injury that severs peripheral nerves often results in long-lasting motor behavioral deficits and
in reorganization of related spinal motor circuitry, neither of which reverse even after nerve …

Current state of neuroprotective therapy using antibiotics in human traumatic brain injury and animal models

K Ritter, P Somnuke, L Hu, EV Griemert… - BMC neuroscience, 2024 - Springer
TBI is a leading cause of death and disability in young people and older adults worldwide.
There is no gold standard treatment for TBI besides surgical interventions and symptomatic …