Sequence-Augmented SE (3)-Flow Matching For Conditional Protein Backbone Generation
Proteins are essential for almost all biological processes and derive their diverse functions
from complex 3D structures, which are in turn determined by their amino acid sequences. In …
from complex 3D structures, which are in turn determined by their amino acid sequences. In …
Full-Atom Peptide Design based on Multi-modal Flow Matching
Peptides, short chains of amino acid residues, play a vital role in numerous biological
processes by interacting with other target molecules, offering substantial potential in drug …
processes by interacting with other target molecules, offering substantial potential in drug …
Secondary Structure-Guided Novel Protein Sequence Generation with Latent Graph Diffusion
The advent of deep learning has introduced efficient approaches for de novo protein
sequence design, significantly improving success rates and reducing development costs …
sequence design, significantly improving success rates and reducing development costs …
PocketGen: Generating Full-Atom Ligand-Binding Protein Pockets
Designing small-molecule-binding proteins, such as enzymes and biosensors, is essential
in protein biology and bioengineering. Generating high-fidelity protein pockets—areas …
in protein biology and bioengineering. Generating high-fidelity protein pockets—areas …