Adiponectin is the most abundant peptide secreted by adipocytes, being a key component in
the interrelationship between adiposity, insulin resistance and inflammation. Central obesity …

Phosphatidylinositol 3 kinase (PI3K) is a key molecule in the initiation of signal transduction
pathways after the binding of extracellular signals to cell surface receptors. An intracellular …

Adipose tissue secretes protein factors that have systemic actions on cardiovascular tissues.
Previous studies have shown that ablation of the adipocyte-secreted protein adiponectin …

BPC 157, a pentadecapeptide with extensive healing effects, has recently been suggested
to contribute to angiogenesis. However, the underlying mechanism is not yet clear. The …

Human pituitary adenomas are the most common intracranial neoplasms. Approximately 5%
of them are familial adenomas. Patients with familial tumors carry germline mutations in …

As a non-canonical member of cadherin superfamily, T-cadherin was initially described as a
molecule involved in homophilic recognition in the nervous and vascular systems. The …

Background—Peripheral arterial disease (PAD) is a clinical condition caused by an
atherosclerotic process affecting the arteries of the limbs. Despite major improvements in …

Individuals with type 2 diabetes (T2D) display vascular insulin resistance and decreased
nitric oxide production leading to vasoconstriction and atherosclerosis. Soluble factors such …

Aims: Fibroblast growth factor 21 (FGF21) is a powerful endocrine hormone modulating
glucose and lipid metabolism and represents a promising drug for type 2 diabetes. The …

Variants in the CDH13 gene have been identified as determinants of blood levels of
adiponectin, an insulin-sensitizing adipokine. However, their association with other …