Since the definition of the “12 Principles of Green Chemistry” more than 20 years ago,
chemists have become increasingly mindful of the need to conserve natural resources and …

Transition-metal catalyzed reactions that are able to construct complex aliphatic amines from
simple, readily available feedstocks have become a cornerstone of modern synthetic …

In the field of C–H bond functionalization chemistry, directed C–H bond activation strategies
are highly appreciated due to the high efficiency and selectivity of such reactions towards a …

Radical C–H functionalization represents a useful means of streamlining synthetic routes by
avoiding substrate preactivation and allowing access to target molecules in fewer steps. The …

Despite decades of ground-breaking research in academia, organic synthesis is still a rate-
limiting factor in drug-discovery projects. Here we present some current challenges in …

Catalytic transformation of ubiquitous C–H bonds into valuable C–N bonds offers an efficient
synthetic approach to construct N-functionalized molecules. Over the last few decades …

Catalytic C–H bond activation, which was an elusive subject of chemical research until the
1990s, has now become a standard synthetic method for the formation of new C–C and C …

The present review “Iron Catalysis in Organic Synthesis” covers the literature until the end of
June 2014 and represents a comprehensive update of a previous article published by Bolm …

1. INTRODUCTION Phthalocyanine metal complexes 1, 2 (MPc's) are structurally related to
porphyrin complexes (Figure 1), which are widely used by nature in the active sites of …

Natural enzymes contain highly evolved active sites that lead to fast rates and high
selectivities. Although artificial metalloenzymes have been developed that catalyze …