Mitochondrial disorders are among the most frequent inborn errors of metabolism, their
primary cause being the dysfunction of the oxidative phosphorylation system (OXPHOS) …

The sequential flow of electrons in the respiratory chain, from a low reduction potential
substrate to O2, is mediated by protein-bound redox cofactors. In mitochondria, hemes …

Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for
virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed …

The mitochondrion is arguably the most complex organelle in the budding yeast cell
cytoplasm. It is essential for viability as well as respiratory growth. Its innermost aqueous …

Heme is the prosthetic group for cytochromes, which are directly involved in
oxidation/reduction reactions inside and outside the cell. Many cytochromes contain heme …

Cellular iron homeostasis and mitochondrial iron homeostasis are interdependent.
Mitochondria must import iron to form iron–sulfur clusters and heme, and to incorporate …

Energy generation by mitochondrial respiration is an absolute requirement for cardiac
function. Here, we used a heart-specific conditional knockout approach to inactivate the X …

Intracellular parasites of the phylum Apicomplexa harbor a plastid-like organelle called
apicoplast that is the most reduced organelle of this type known. Due to the medical …

Mitochondrial disorders are clinical syndromes associated with abnormalities of the
oxidative phosphorylation (OXPHOS) system, the main responsible for the production of …

The cytochrome bc1 complex is an essential component of the electron transport chain in
most prokaryotes and in eukaryotic mitochondria. The catalytic subunits of the complex that …