The protein α‐synuclein has a central role in the pathogenesis of Parkinson's disease (PD).
In this review, we discuss recent results concerning its primary function, which appears to be …

Parkinson's disease (PD) is characterized by intracellular inclusions of aggregated and
misfolded α-Synuclein (α-Syn), and the loss of dopaminergic (DA) neurons in the brain. The …

Parkinson's disease (PD) is one of the most common neurodegenerative disorders, affecting
1–1.5% of the total population. While progress has been made in understanding the …

Endocannabinoids are among the most powerful modulators of synaptic transmission
throughout the nervous system, and yet little is understood about the release of …

Parkinson's disease (PD) is characterized pathologically by the selective loss of substantia
nigra (SN) dopaminergic (DAergic) neurons. Recent evidence has suggested a role of …

Neurotransmission relies critically on the exocytotic release of neurotransmitters from small
synaptic vesicles (SVs) at the active zone. Therefore, it is essential for neurons to maintain …

α-Synuclein is known as a presynaptic protein that binds to small synaptic vesicles. Recent
studies suggest that α-synuclein is not only attracted to these tiny and therewith highly …

α-synuclein (α-Syn) is a presynaptic enriched protein involved in the pathogenesis of
Parkinson's disease. However, the physiological roles of α-Syn remain poorly understood …

Synapse is the basic structural and functional component for neural communication in the
brain. The presynaptic terminal is the structural and functionally essential area that initiates …

Specific proteins accumulate in neurodegenerative disease, and human genetics has
indicated a causative role for many. In most cases, however, the mechanisms remain poorly …