Non-alcoholic fatty liver disease and dyslipidemia: an update

N Katsiki, DP Mikhailidis, CS Mantzoros - Metabolism, 2016 - Elsevier
Non-alcoholic fatty liver (NAFLD) is the most common liver disease worldwide, progressing
from simple steatosis to necroinflammation and fibrosis (leading to non-alcoholic …

Role of blood-brain barrier in Alzheimer's disease

Z Cai, PF Qiao, CQ Wan, M Cai… - Journal of Alzheimer's …, 2018 - content.iospress.com
The blood-brain barrier (BBB) is involved in the pathogenesis of Alzheimer's disease (AD).
BBB is a highly selective semipermeable structural and chemical barrier which ensures a …

Wnt/β-catenin signaling in liver cancers

W Wang, R Smits, H Hao, C He - Cancers, 2019 - mdpi.com
Liver cancer is among the leading global healthcare issues associated with high morbidity
and mortality. Liver cancer consists of hepatocellular carcinoma (HCC), cholangiocarcinoma …

Multifactorial basis and therapeutic strategies in metabolism-related diseases

JVS Guerra, MMG Dias, AJVC Brilhante, MF Terra… - Nutrients, 2021 - mdpi.com
Throughout the 20th and 21st centuries, the incidence of non-communicable diseases
(NCDs), also known as chronic diseases, has been increasing worldwide. Changes in …

LRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration

Y Wu, L Zhou, H Liu, R Duan, H Zhou, F Zhang, X He… - Cell research, 2021 - nature.com
The adult mammalian heart is thought to be a terminally differentiated organ given the
postmitotic nature of cardiomyocytes. Consequently, the potential for cardiac repair through …

Wnt signaling in cardiovascular disease: opportunities and challenges

A Gay, DA Towler - Current opinion in lipidology, 2017 - journals.lww.com
Components of the Wnt signaling cascade represent novel targets for pharmacological
intervention in cardiometabolic disease. Conversely, strategies targeting the Wnt signaling …

LncRNA MEG3 functions as a ceRNA in regulating hepatic lipogenesis by competitively binding to miR-21 with LRP6

P Huang, F Huang, H Liu, T Zhang, M Yang, C Sun - Metabolism, 2019 - Elsevier
Background Hepatic lipogenesis dysregulation is essential for the development of non-
alcoholic fatty liver disease (NAFLD). Emerging evidence indicates the importance of the …

Arterial hypertension, obesity and non-alcoholic fatty liver disease: is there any connection?

NV Kuzminova, OV Gribenyuk… - Arterial …, 2016 - journals.viamedica.pl
The combination of hypertension, obesity and non-alcoholic fatty liver disease occurs in
medical practice very often. A number of studies have shown that non-alcoholic fatty liver …

Exosomal circFBLIM1 promotes hepatocellular carcinoma progression and glycolysis by regulating the miR-338/LRP6 axis

Z Lai, T Wei, Q Li, X Wang, Y Zhang… - Cancer biotherapy & …, 2023 - liebertpub.com
Background: Hepatocellular carcinoma (HCC) is the most common form of liver cancer.
Circular RNAs (circRNAs) play a vital role in cancer development and progression. This …

A comprehensive review of long non-coding RNAs in the pathogenesis and development of non-alcoholic fatty liver disease

AG Shabgah, F Norouzi, M Hedayati-Moghadam… - Nutrition & …, 2021 - Springer
One of the most prevalent diseases worldwide without a fully-known mechanism is non-
alcoholic fatty liver disease (NAFLD). Recently, long non-coding RNAs (lncRNAs) have …