[HTML][HTML] Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets

X Di, X Gao, L Peng, J Ai, X Jin, S Qi, H Li… - Signal transduction and …, 2023 - nature.com
Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Interplay between mechanics and signalling in regulating cell fate

H De Belly, EK Paluch, KJ Chalut - Nature Reviews Molecular Cell …, 2022 - nature.com
Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …

[HTML][HTML] Mechanoregulation of YAP and TAZ in cellular homeostasis and disease progression

X Cai, KC Wang, Z Meng - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Biophysical cues, such as mechanical properties, play a critical role in tissue growth and
homeostasis. During organ development and tissue injury repair, compressive and tensional …

[HTML][HTML] Cellular mechanotransduction: from tension to function

F Martino, AR Perestrelo, V Vinarský, S Pagliari… - Frontiers in …, 2018 - frontiersin.org
Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

[HTML][HTML] Age-related matrix stiffening epigenetically regulates α-Klotho expression and compromises chondrocyte integrity

H Iijima, G Gilmer, K Wang, AC Bean, Y He… - Nature …, 2023 - nature.com
Extracellular matrix stiffening is a quintessential feature of cartilage aging, a leading cause
of knee osteoarthritis. Yet, the downstream molecular and cellular consequences of age …

Biointerface design for vertical nanoprobes

R Elnathan, MG Barbato, X Guo, A Mariano… - Nature Reviews …, 2022 - nature.com
Biointerfaces mediate safe and efficient cell manipulation, which is essential for biomedical
innovations in advanced therapies and diagnostics. The biointerface established by vertical …

Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment

G Huang, F Li, X Zhao, Y Ma, Y Li, M Lin, G Jin… - Chemical …, 2017 - ACS Publications
The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

[HTML][HTML] Design challenges in polymeric scaffolds for tissue engineering

MI Echeverria Molina, KG Malollari… - … in Bioengineering and …, 2021 - frontiersin.org
Numerous surgical procedures are daily performed worldwide to replace and repair
damaged tissue. Tissue engineering is the field devoted to the regeneration of damaged …

Genetics of thoracic and abdominal aortic diseases: aneurysms, dissections, and ruptures

A Pinard, GT Jones, DM Milewicz - Circulation research, 2019 - Am Heart Assoc
Dissections or ruptures of aortic aneurysms remain a leading cause of death in the
developed world, with the majority of deaths being preventable if individuals at risk are …

Integrin-mediated mechanotransduction

Z Sun, SS Guo, R Fässler - Journal of Cell Biology, 2016 - rupress.org
Cells can detect and react to the biophysical properties of the extracellular environment
through integrin-based adhesion sites and adapt to the extracellular milieu in a process …